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首页> 外文期刊>Antimicrobial agents and chemotherapy. >Influence of Clarithromycin on Early Atherosclerotic Lesions after Chlamydia pneumoniae Infection in a Rabbit Model.
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Influence of Clarithromycin on Early Atherosclerotic Lesions after Chlamydia pneumoniae Infection in a Rabbit Model.

机译：克拉霉素对兔模型中肺炎衣原体感染后早期动脉粥样硬化病变的影响。

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Chlamydia pneumoniae may play a role in atherogenesis and vascular diseases, and antibiotics may prove useful in these conditions. Three groups of New Zealand White rabbits (24 per group) were infected via the nasopharynx with C. pneumoniae on three separate occasions (2 weeks apart). Group I was untreated and sacrificed at 12 weeks; group II received clarithromycin at 20 mg/kg/day for 8 days, beginning 5 days after each inoculation (early treatment); and group III received a similar dose of clarithromycin starting 2 weeks after the third inoculation and continued for 6 weeks thereafter (delayed treatment). To test for a possible anti-inflammatory effect of clarithromycin, two other groups of uninfected rabbits (12 animals in each) were fed 0.5% cholesterol-enriched chow, and one of these groups was treated with clarithromycin at 30 mg/kg/day for 6 weeks. Of 23 untreated infected rabbits, 8 developed early lesions of atherosclerosis, whereas 2 of the 24 early-treated group II had similar changes (P = 0.036 [75% efficacy]). However, in the delayed-treatment group, group III, 3 of 24 rabbits developed early lesions of atherosclerosis, thus demonstrating 62.5% reduction compared to the untreated controls (P = 0.07 [trend to statistical significance]). C. pneumoniae antigen was detected in 8 of 23 group I (untreated) rabbits versus 1 of 24 of the early-treated (group II) rabbits and 4 of 24 animals in the delayed group III (P = 0.009 and 0.138, respectively). All of the untreated, cholesterol-fed rabbits had moderate to advanced atherosclerosis (grade III or IV); clarithromycin had no effect on reducing the prevalence of but did reduce the extent of atherosclerosis in the cholesterol-fed rabbits by 17% compared to untreated controls. Thus, clarithromycin administration modified C. pneumoniae-induced atherosclerotic lesions and reduced the ability to detect organism in tissue. Early treatment was more effective than delayed treatment.
机译：肺炎衣原体可能在动脉粥样硬化和血管疾病中起作用，抗生素可能在这些情况下有用。三组新西兰白兔（每组24只）在三个不同的场合（相隔2周）通过鼻咽感染了肺炎衣原体。第一组未经治疗并在第12周处死; II组在每次接种后5天开始接受20毫克/千克/天的克拉霉素治疗，持续8天（早期治疗）;第三次接种后第2周开始，第III组和第3组接受类似剂量的克拉霉素，此后持续6周（延迟治疗）。为了测试克拉霉素的可能的抗炎作用，另两组未感染的兔子（每只12只动物）被喂食0.5％富含胆固醇的食物，其中一组以克拉霉素30 mg / kg /天治疗， 6个星期在23只未经治疗的感染兔子中，有8只出现了动脉粥样硬化的早期病变，而24只早期治疗的II组中有2只具有相似的变化（P = 0.036 [75％疗效]）。但是，在延迟治疗组中，第三组的24只兔子中有3只出现了动脉粥样硬化的早期病变，因此与未治疗的对照组相比，减少了62.5％（P = 0.07 [趋向统计学意义]）。在第I组（未治疗）的23只兔中有8只检测到肺炎衣原体抗原，而在第III组延迟的24只动物中，有24只动物中有1只检测到了肺炎衣原体抗原（分别为P = 0.009和0.138）。所有未经胆固醇喂养的未经治疗的兔均患有中度至晚期的动脉粥样硬化（III或IV级）。与未经治疗的对照组相比，克拉霉素对降低其患病率没有影响，但确实使胆固醇喂养的兔的动脉粥样硬化程度降低了17％。因此，克拉霉素的施用改变了肺炎衣原体诱导的动脉粥样硬化病变，并降低了检测组织中生物的能力。早期治疗比延迟治疗更有效。

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