Attenuated vancomycin bactericidal activity against Staphylococcus aureus hemB mutants expressing the small-colony-variant phenotype.

Tsuji BT; von-Eiff C; Kelchlin PA; Forrest A; Smith PF

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Attenuated vancomycin bactericidal activity against Staphylococcus aureus hemB mutants expressing the small-colony-variant phenotype.

机译：万古霉素对表达小菌落变异表型的金黄色葡萄球菌hemB突变体的杀菌活性减弱。

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The in vitro bactericidal activities of vancomycin against Staphylococcus aureus hemB mutants displaying the small-colony-variant phenotype and their parental strains were evaluated. Vancomycin killing activities against hemB mutants were markedly attenuated, demonstrating approximately 50% less effect, a result which was well described by a Hill-type pharmacodynamic model.

机译：评估了万古霉素对显示小菌落变异表型的金黄色葡萄球菌hemB突变体及其亲本菌株的体外杀菌活性。对hemB突变体的万古霉素杀伤活性显着减弱，显示效果降低了约50％，这一结果已被Hill型药效学模型很好地描述。

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《Antimicrobial agents and chemotherapy.》 |2008年第4期|共5页
作者
Tsuji BT; von-Eiff C; Kelchlin PA; Forrest A; Smith PF;
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正文语种 eng
中图分类治疗学;
关键词
Vancomycin; Staphylococcus aureus; Phenotype; Attenuated by; Vancomycin Assay; 万古霉素; 葡萄球菌; 金黄色; 表型;

机译：Vancomycin;Staphylococcus aureus;Phenotype;Attenuated by;Vancomycin Assay;万古霉素;葡萄球菌;金黄色;表型;

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1. Attenuated vancomycin bactericidal activity against Staphylococcus aureus hemB mutants expressing the small-colony-variant phenotype. [J] . Tsuji BT, von-Eiff C, Kelchlin PA, Antimicrobial agents and chemotherapy. . 2008,第4期

机译：万古霉素对表达小菌落变异表型的金黄色葡萄球菌hemB突变体的杀菌活性减弱。
2. Phenotype Microarray Profiling of Staphylococcus aureus menD and hemB Mutants with the Small-Colony-Variant Phenotype [J] . Christof von Eiff, Peter McNamara, Karsten Becker, Journal of bacteriology . 2006,第2期

机译：表型微阵列分析金黄色葡萄球菌menD和hemB突变体的小殖民地-变种表型。
3. Extracellular and intracellular bactericidal activities of XF-70 against small-colony variant hemB mutants of meticillin-susceptible and meticillin-resistant Staphylococcus aureus [J] . Vaudaux P., Huggler E., Rhys-Williams W., International journal of antimicrobial agents . 2011,第6期

机译：XF-70对易感和耐甲氧西林金黄色葡萄球菌的小菌落hemB突变体的细胞外和细胞内杀菌活性
4. Synergistic Antibacterial Activities of Bioactive Compounds from Streptomyces sp. RS2 in Combination with Vancomycin against Staphylococcus aureus [C] . Nongyao Nonpanya, Suwanna Niamsanit, Kwanjai Kanokmedhakul, IEEE International Conference on Engineering Technologies and Applied Sciences . 2018

机译：链霉菌属生物活性化合物的协同抗菌活性。 RS2联合万古霉素抗金黄色葡萄球菌
5. Transcriptomic and metabolomic comparison of select vancomycin intermediate staphylococcus aureus (VISA) strains to their parent and the effect of fatty acid content in staphylococcus aureus on antimicrobial susceptibility analysis [D] . Hattangady, Dipti S. J. 2014

机译：选定的万古霉素金黄色葡萄球菌（VISA）菌株与其亲本的转录组学和代谢组学比较，以及金黄色葡萄球菌中脂肪酸含量对抗菌素敏感性分析的影响
6. Attenuated Vancomycin Bactericidal Activity against Staphylococcus aureus hemB Mutants Expressing the Small-Colony-Variant Phenotype [O] . Brian T. Tsuji, Christof von Eiff, Pamela A. Kelchlin, 2008

机译：万古霉素对金黄色葡萄球菌hemB突变体表达小菌落-变种表型的杀菌活性。
7. Attenuated Vancomycin Bactericidal Activity against Staphylococcus aureus hemB Mutants Expressing the Small-Colony-Variant Phenotype▿ [O] . Tsuji, Brian T., von Eiff, Christof, Kelchlin, Pamela A., 2008

机译：万古霉素对金黄色葡萄球菌hemB突变体表达小菌落-变种表型的杀菌活性▿

Attenuated vancomycin bactericidal activity against Staphylococcus aureus hemB mutants expressing the small-colony-variant phenotype.

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