Antiretroviral therapy with a twice-daily regimen containing 400 milligrams of indinavir and 100 milligrams of ritonavir in human immunodeficiency virus type 1-infected women during pregnancy.

Ghosn J; De-Montgolfier I; Cornelie C; Dominguez S; Perot C; Peytavin G; Marcelin AG; Pauchard M; Ouagari Z; Bonmarchand M; Agher R; Calvez V; Bricaire F; Dommergues M; Katlama C; Tubiana R

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Antiretroviral therapy with a twice-daily regimen containing 400 milligrams of indinavir and 100 milligrams of ritonavir in human immunodeficiency virus type 1-infected women during pregnancy.

机译：在怀孕期间，每天两次两次接受抗人免疫缺陷病毒1型感染的妇女的抗逆转录病毒疗法，其中包含400毫克的茚地那韦和100毫克的利托那韦。

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We evaluated the safety and efficacy of a twice daily regimen containing 400 mg of indinavir and 100 mg of ritonavir in 32 human immunodeficiency virus (HIV)-infected women during pregnancy. The median indinavir trough concentration was 208 ng/ml during the third trimester. At delivery, 26 of 28 women on indinavir-ritonavir had HIV RNA levels of <200 copies/ml. No infant was HIV infected. These data are encouraging for the use of this combination for prevention of mother-to-child transmission of HIV.

机译：我们评估了在妊娠期间32位人类免疫缺陷病毒（HIV）感染的妇女中，每天服用两次400 mg茚地那韦和100 mg利托那韦的方案的安全性和有效性。在妊娠中期，茚地那韦谷浓度中位数为208 ng / ml。分娩时，使用茚地那韦-利托那韦的28名妇女中有26名的HIV RNA水平<200拷贝/毫升。没有婴儿感染艾滋病毒。这些数据对于将这种组合用于预防HIV母婴传播令人鼓舞。

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《Antimicrobial agents and chemotherapy.》 |2008年第4期|共3页
作者
Ghosn J; De-Montgolfier I; Cornelie C; Dominguez S; Perot C; Peytavin G; Marcelin AG; Pauchard M; Ouagari Z; Bonmarchand M; Agher R; Calvez V; Bricaire F; Dommergues M; Katlama C; Tubiana R;
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正文语种 eng
中图分类治疗学;
关键词
HIV; Indinavir; Ritonavir; Human Females; regimen; 英地纲韦; 利托纳韦;

机译：HIV;Indinavir;Ritonavir;Human Females;regimen;英地纲韦;利托纳韦;

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1. Antiretroviral therapy with a twice-daily regimen containing 400 milligrams of indinavir and 100 milligrams of ritonavir in human immunodeficiency virus type 1-infected women during pregnancy. [J] . Ghosn J, De-Montgolfier I, Cornelie C, Antimicrobial agents and chemotherapy. . 2008,第4期

机译：在怀孕期间，每天两次两次接受抗人免疫缺陷病毒1型感染的妇女的抗逆转录病毒疗法，其中包含400毫克的茚地那韦和100毫克的利托那韦。
2. Pharmacokinetics of indinavir and ritonavir administered at 667 and 100 milligrams, respectively, every 12 hours compared with indinavir administered at 800 milligrams every 8 hours in human immunodeficiency virus-infected patients. [J] . Rhame FS, Rawlins SL, Petruschke RA, Antimicrobial agents and chemotherapy. . 2004,第11期

机译：在感染人类免疫缺陷病毒的患者中，茚地那韦和利托那韦的药代动力学分别为每12小时667和100毫克，而茚地那韦每8个小时以800毫克的药代动力学。
3. Lopinavir/ritonavir-based antiretroviral therapy in human immunodeficiency virus type 1-infected naive children: rare protease inhibitor resistance mutations but high lamivudine/emtricitabine resistance at the time of virologic failure. [J] . Frange P, Briand N, Avettand fenoel V, The Pediatric infectious disease journal . 2011,第8期

机译：基于罗匹那韦/利托那韦的抗逆转录病毒疗法在1型人类免疫缺陷病毒感染的纯净儿童中的应用：罕见的蛋白酶抑制剂耐药性突变，但病毒学失败时拉米夫定/恩曲他滨耐药性高。
4. Characterization of the human immunodeficiency virus type 1-specific humoral immune response during highly active antiretroviral therapy. [D] . Morris, Mary Kathleen. 2000

机译：高免疫活性抗逆转录病毒治疗过程中人类免疫缺陷病毒1型特异性体液免疫反应的特征。
5. Antiretroviral Therapy with a Twice-Daily Regimen Containing 400 Milligrams of Indinavir and 100 Milligrams of Ritonavir in Human Immunodeficiency Virus Type 1-Infected Women during Pregnancy [O] . Jade Ghosn, Ines De Montgolfier, Chantal Cornélie, 2008

机译：在人类免疫缺陷病毒1型感染妇女中两次每日两次包含400毫克茚地那韦和100毫克利托那韦的抗逆转录病毒疗法。
6. Antiretroviral Therapy with a Twice-Daily Regimen Containing 400 Milligrams of Indinavir and 100 Milligrams of Ritonavir in Human Immunodeficiency Virus Type 1-Infected Women during Pregnancy▿ [O] . Ghosn, Jade, De Montgolfier, Ines, Cornélie, Chantal, 2008

机译：在人类免疫缺陷病毒1型感染妇女中，每天两次接受包含400毫克茚地那韦和100毫克利托那韦的抗逆转录病毒疗法▿

Antiretroviral therapy with a twice-daily regimen containing 400 milligrams of indinavir and 100 milligrams of ritonavir in human immunodeficiency virus type 1-infected women during pregnancy.

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