In vitro activities of BMS-207147 against over 600 contemporary clinical bloodstream isolates of Candida species from the SENTRY Antimicrobial Surveillance Program in North America and Latin America.

Diekema DJ; Pfaller MA; Messer SA; Houston A; Hollis RJ; Doern GV; Jones RN

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In vitro activities of BMS-207147 against over 600 contemporary clinical bloodstream isolates of Candida species from the SENTRY Antimicrobial Surveillance Program in North America and Latin America.

机译：BMS-207147针对来自北美和拉丁美洲SENTRY抗菌监测计划的600多种当代念珠菌临床分离株的体外活性。

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We compared the in vitro activity of BMS-207147, an investigational triazole, with those of itraconazole and fluconazole against 613 clinical bloodstream isolates of Candida spp. collected from SENTRY participating hospitals during 1997 and 1998. Overall, BMS-207147 was the most active azole against all Candida spp. While both BMS-207147 and itraconazole displayed a stepwise decrease in activity against isolates for which the fluconazole MICs were elevated, BMS-207147 had two- to fourfold greater activity than itraconazole both against Candida spp. that were dose-dependently fluconazole susceptible and against those that were fluconazole resistant.

机译：我们比较了正在研究的三唑BMS-207147与伊曲康唑和氟康唑对613种念珠菌临床血液分离株的体外活性。在1997年至1998年期间，这些药物是从SENTRY参与医院收集的。总体而言，BMS-207147是对抗所有假丝酵母菌活性最强的唑。虽然BMS-207147和伊曲康唑对氟康唑MICs升高的分离株的活性均呈逐步降低的趋势，但BMS-207147的抗假丝酵母活性均比伊曲康唑高2-4倍。氟康唑对剂量敏感，对氟康唑耐药。

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来源
《Antimicrobial agents and chemotherapy.》 |1999年第9期|共4页
作者
Diekema DJ; Pfaller MA; Messer SA; Houston A; Hollis RJ; Doern GV; Jones RN;
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正文语种 eng
中图分类治疗学;
关键词
Antifungal Agents; Candida; Fluconazole; Itraconazole; Thiazoles; Triazoles; 抗真菌药; 念珠菌属; 氟康唑; 伊曲康唑; 噻唑类; 三唑类;

机译：Antifungal Agents;Candida;Fluconazole;Itraconazole;Thiazoles;Triazoles;抗真菌药;念珠菌属;氟康唑;伊曲康唑;噻唑类;三唑类;

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1. In vitro activities of BMS-207147 against over 600 contemporary clinical bloodstream isolates of Candida species from the SENTRY Antimicrobial Surveillance Program in North America and Latin America. [J] . Diekema DJ, Pfaller MA, Messer SA, Antimicrobial agents and chemotherapy. . 1999,第9期

机译：BMS-207147针对来自北美和拉丁美洲SENTRY抗菌监测计划的600多种当代念珠菌临床分离株的体外活性。
2. Bloodstream infections due to Candida species: SENTRY antimicrobial surveillance program in North America and Latin America, 1997-1998. [J] . Pfaller MA, Jones RN, Doern GV, Antimicrobial agents and chemotherapy. . 2000,第3期

机译：念珠菌引起的血液感染：北美和拉丁美洲的SENTRY抗菌药物监测计划，1997-1998年。
3. Salmonella spp. isolates causing bloodstream infections in Latin America: report of antimicrobial activity from the SENTRY Antimicrobial Surveillance Program (1997-2000). [J] . Gales AC, Sader HS, Mendes RE, Diagnostic microbiology and infectious disease . 2002,第3期

机译：沙门氏菌拉丁美洲引起血液感染的分离株：SENTRY抗菌监测计划（1997-2000）的抗菌活性报告。
4. In vitro susceptibility of north american field isolates of porcine Serpulina pilqsicou to four antimicrobials [C] . G. E. Duhamel, J. M. Kinyon, M. R. Mathiesen, Congress of the International Pig Veterinary Society . 1999

机译：北美野生植物猪丝氨酸菌菌离体的体外易感性四种抗菌药物
5. In Vitro Activities of BMS-207147 against Over 600 Contemporary Clinical Bloodstream Isolates of Candida Species from the SENTRY Antimicrobial Surveillance Program in North America and Latin America [O] . D. J. Diekema, M. A. Pfaller, S. A. Messer, 1999

机译：BMS-207147对来自北美和拉丁美洲SENTRY抗菌监测计划的600多种现代念珠菌临床血液分离株的体外活性
6. Bloodstream Infections Due to Candida Species: SENTRY Antimicrobial Surveillance Program in North America and Latin America, 1997-1998 [O] . Pfaller, M. A., Jones, R. N., Doern, G. V., 2000

机译：念珠菌引起的血流感染：SENTRY北美和拉丁美洲抗菌监测计划，1997-1998年

In vitro activities of BMS-207147 against over 600 contemporary clinical bloodstream isolates of Candida species from the SENTRY Antimicrobial Surveillance Program in North America and Latin America.

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