Genetic characterization of resistance to extended-spectrum beta-lactams in Klebsiella oxytoca isolates recovered from patients with septicemia at hospitals in the Stockholm area.

Wu SW; Dornbusch K; Kronvall G

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Genetic characterization of resistance to extended-spectrum beta-lactams in Klebsiella oxytoca isolates recovered from patients with septicemia at hospitals in the Stockholm area.

机译：从斯德哥尔摩地区败血症患者中回收的产酸克雷伯菌分离株对广谱β-内酰胺类耐药的遗传特征。

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Two beta-lactamase gene regions were characterized by DNA sequencing in eight clinical isolates of Klebsiella oxytoca. The blaOXY-2a region encoded a beta-lactamase nearly identical to OXY-2 (one amino acid residue substituted) and conferred aztreonam and cefuroxime resistance on the K. oxytoca isolates. Overproduction of OXY-2a was caused by a G-to-A substitution of the fifth nucleotide in the -10 consensus sequence of blaOXY-2a. The blaOXY-1a was identified in a susceptible strain, and the OXY-1a enzyme differed from OXY-1 by two amino acid residues.

机译：通过DNA测序在八株产酸克雷伯菌的临床分离株中鉴定了两个β-内酰胺酶基因区域。 blaOXY-2a区编码的β-内酰胺酶几乎与OXY-2（一个氨基酸残基被取代）相同，并赋予产氧假单胞菌分离物以氨曲南和头孢呋辛抗性。 OXY-2a的过量生产是由blaOXY-2a -10共有序列中的第五个核苷酸的G-to-A取代引起的。在易感菌株中鉴定出blaOXY-1a，OXY-1a酶与OXY-1的区别在于两个氨基酸残基。

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《Antimicrobial agents and chemotherapy.》 |1999年第5期|共4页
作者
Wu SW; Dornbusch K; Kronvall G;
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正文语种 eng
中图分类治疗学;
关键词
beta Lactam Resistance genetics; beta-Lactamases; Bacteremia; Klebsiella; β内酰胺酶类; 菌血症; 克雷伯氏菌属; 克雷伯氏菌感染;

机译：beta Lactam Resistance genetics;beta-Lactamases;Bacteremia;Klebsiella;β内酰胺酶类;菌血症;克雷伯氏菌属;克雷伯氏菌感染;

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1. Genetic characterization of resistance to extended-spectrum beta-lactams in Klebsiella oxytoca isolates recovered from patients with septicemia at hospitals in the Stockholm area. [J] . Wu SW, Dornbusch K, Kronvall G Antimicrobial agents and chemotherapy. . 1999,第5期

机译：从斯德哥尔摩地区败血症患者中回收的产酸克雷伯菌分离株对广谱β-内酰胺类耐药的遗传特征。
2. Activity of NXL104 in combination with beta-lactams against genetically characterized Escherichia coli and Klebsiella pneumoniae isolates producing class A extended-spectrum beta-lactamases and class C beta-lactamases. [J] . Lagace Wiens PR, Tailor F, Simner P, Antimicrobial agents and chemotherapy. . 2011,第5期

机译：NXL104与β-内酰胺类组合物对具有遗传特征的大肠埃希菌和肺炎克雷伯菌的分离物的活性，可产生A类广谱β-内酰胺酶和C类β-内酰胺酶。
3. Evaluation of the Clinical and Laboratory Standards Institute phenotypic confirmatory test to detect the presence of extended-spectrum β-lactamases from 4005 Escherichia coli, Klebsiella oxytoca, Klebsiella pneumoniae and Proteus mirabilis isolates [J] . Ian Morrissey, Samuel K. Bouchillon, Meredith Hackel, Journal of Medical Microbiology: An Official Journal of the Pathological Society of Great Britain and Ireland . 2014,第4期

机译：对临床和实验室标准协会表型确认试验的评估，以检测来自4005大肠杆菌，产酸克雷伯菌，肺炎克雷伯菌和奇异变形杆菌分离株的广谱β-内酰胺酶
4. The prevalence and characterization of ESBLs producing isolates of klebsiella pneumoniae in some major hospitals, Jilin region [C] . Li-hua Chen, Ming-cheng Li, Yan-yan Wang, 2011 International Conference on Human Health and Biomedical Engineering . 2011

机译：吉林地区一些主要医院生产ESBLs的肺炎克雷伯菌的分离株的流行和特征
5. Analysis of the resistance in genetically engineered papaya against papaya ringspot potyvirus, partial characterization of the PRSV.Brazil.Bahia isolate, and development of transgenic papaya for Brazil. [D] . Souza, Manoel Teixeira, Junior. 1999

机译：分析基因工程木瓜对木瓜环斑杯状病毒的抗性，PRSV.Brazil.Bahia分离株的部分特征以及巴西转基因木瓜的开发。
6. Note: Genetic Characterization of Resistance to Extended-Spectrum β-Lactams in Klebsiella oxytoca Isolates Recovered from Patients with Septicemia at Hospitals in the Stockholm Area [O] . Shang Wei Wu, Kathrine Dornbusch, Göran Kronvall 1999

机译：注意：在斯德哥尔摩地区医院败血症患者中发现的产酸克雷伯菌分离株对广谱β-内酰胺的抗性的遗传特征
7. Bases of variation in resistance to beta-lactams in Klebsiella oxytoca isolates hyperproducing K1 beta-lactamase [O] . R. Gheorghiu, M. Yuan, L. M. Hall, 1997

机译：Klebsiella ocktoca中β-内酰胺抗β-内酰胺的变异碱基分离酸盐酸盐β-内酰胺酶

Genetic characterization of resistance to extended-spectrum beta-lactams in Klebsiella oxytoca isolates recovered from patients with septicemia at hospitals in the Stockholm area.

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