An A643V amino acid substitution in Upc2p contributes to azole resistance in well-characterized clinical isolates of Candida albicans.

Hoot SJ; Smith AR; Brown RP; White TC

首页> 外文期刊>Antimicrobial agents and chemotherapy. >An A643V amino acid substitution in Upc2p contributes to azole resistance in well-characterized clinical isolates of Candida albicans.

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An A643V amino acid substitution in Upc2p contributes to azole resistance in well-characterized clinical isolates of Candida albicans.

机译：Upc2p中的A643V氨基酸取代有助于白色念珠菌临床特征充分的唑耐药性。

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The Candida albicans Upc2p transcription factor regulates ERG11, encoding the target of azole drugs. Gain-of-function mutations that contribute to resistance were recently identified in a series of sequential clinical isolates (N. Dunkel, T. T. Liu, K. S. Barker, R. Homayouni, J. Morschhauser, and P. D. Rogers, Eukaryot. Cell 7:1180-1190, 2008). In the present study, UPC2 was sequenced from a matched set of 17 isolates. An A643V substitution was present in all of the isolates in the series that overexpressed ERG11. Azole susceptibility, ergosterol levels, and expression of ERG genes were elevated in the A643V clinical isolates and in reconstructed strains.

机译：白色念珠菌Upc2p转录因子调节ERG11，编码唑类药物的靶标。最近在一系列连续的临床分离株中鉴定了导致耐药的功能获得性突变（N. Dunkel，TT Liu，KS Barker，R。Homayouni，J。Morschhauser和PD Rogers，Eukaryot。Cell7：1180- 1190，2008）。在本研究中，从匹配的17个分离株中对UPC2进行了测序。 A643V替代存在于过表达ERG11的系列的所有分离物中。在A643V临床分离株和重组菌株中，Azole敏感性，麦角固醇水平和ERG基因表达均升高。

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《Antimicrobial agents and chemotherapy.》 |2011年第2期|共3页
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Hoot SJ; Smith AR; Brown RP; White TC;
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1. An A643V amino acid substitution in Upc2p contributes to azole resistance in well-characterized clinical isolates of Candida albicans. [J] . Hoot SJ, Smith AR, Brown RP, Antimicrobial agents and chemotherapy. . 2011,第2期

机译：Upc2p中的A643V氨基酸取代有助于白色念珠菌临床特征充分的唑耐药性。
2. Screening for amino acid substitutions in the Candida albicans Erg11 protein of azole-susceptible and azole-resistant clinical isolates: new substitutions and a review of the literature. [J] . Morio F, Loge C, Besse B, Diagnostic microbiology and infectious disease . 2010,第4期

机译：筛选对吡咯敏感和对吡咯耐药的临床分离株的白色念珠菌Erg11蛋白中的氨基酸取代：新的取代和文献综述。
3. Multiple amino acid substitutions in lanosterol 14α-demethylase contribute to azole resistance in Candida albicans [J] . Bertrand Favre, Mark Didmon, Neil S. Ryder Microbiology . 1999,第10期

机译：Lanterollol14α-脱甲基酶中的多个氨基酸取代有助于念珠菌白醛植物的抗唑抗性
4. Genetic and antigenic analysis of the hemagglutinin of recent swine influenza virus isolates utilizing a unique software program comparing amino acid substitutions in immunogenic sites [C] . T. Oleson, B. Hause, D.L. Stine, Annual Meeting of the American Association of Swine Veterinarians . 2010

机译：利用独特的软件计划将氨基酸取代在免疫原性位点中的独特软件程序分离素血凝素的遗传和抗原分析
5. A single amino acid substitution in PmrB is associated with polymyxin B resistance in clinical isolate of Pseudomonas aeruginosa. [D] . Abraham, Neethu. 2010

机译：PmrB中的单个氨基酸取代与铜绿假单胞菌临床分离物中的多粘菌素B抗性相关。
6. An A643V Amino Acid Substitution in Upc2p Contributes to Azole Resistance in Well-Characterized Clinical Isolates of Candida albicans [O] . Samantha J. Hoot, Adam R. Smith, Ryan P. Brown, 2011

机译：Upc2p中的A643V氨基酸替代有助于白色念珠菌临床特征明确的偶氮菌抗性。
7. An A643V Amino Acid Substitution in Upc2p Contributes to Azole Resistance in Well-Characterized Clinical Isolates of Candida albicans▿ [O] . Hoot, Samantha J., Smith, Adam R., Brown, Ryan P., 2010

机译：在特征明确的白色念珠菌临床分离株中，Upc2p中的A643V氨基酸取代有助于抗唑的作用▿

An A643V amino acid substitution in Upc2p contributes to azole resistance in well-characterized clinical isolates of Candida albicans.

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