High risk of QT interval prolongation and torsades de pointes associated with intravenous quinidine used for treatment of resistant malaria or babesiosis

WroblewskiH.A.; KovacsR.J.; KingeryJ.R.; OverholserB.R.; TisdaleJ.E.

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High risk of QT interval prolongation and torsades de pointes associated with intravenous quinidine used for treatment of resistant malaria or babesiosis

机译：与静脉注射奎尼丁有关的耐药性疟疾或杆状杆菌病，存在QT间期延长和扭转性高发的高风险

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Cardiac toxicity may be associated with drugs used for malaria. Torsades de pointes (TdP) is a well-known adverse effect of quinidine when used for atrial fibrillation. Intravenous quinidine doses for resistant malaria are 2 to 3 times higher than those used for arrhythmias. Among 6 patients receiving quinidine for malaria or babesiosis, 4 developed QT interval prolongation and 2 experienced TdP. Clinicians should be aware that recommended doses of quinidine for malaria carry a high TdP risk.

机译：心脏毒性可能与用于疟疾的药物有关。尖端扭转型眼病（TsP）是奎尼丁用于房颤时的一种众所周知的不良反应。耐药性疟疾的静脉注射奎尼丁剂量比心律不齐使用剂量高2至3倍。在接受奎尼丁治疗的疟疾或杆状菌病的6例患者中，有4例出现QT间期延长，2例经历了TdP。临床医生应意识到，推荐的奎尼丁剂量用于疟疾具有很高的TdP风险。

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《Antimicrobial agents and chemotherapy.》 |2012年第8期|共5页
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WroblewskiH.A.; KovacsR.J.; KingeryJ.R.; OverholserB.R.; TisdaleJ.E.;
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正文语种 eng
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1. High risk of QT interval prolongation and torsades de pointes associated with intravenous quinidine used for treatment of resistant malaria or babesiosis [J] . WroblewskiH.A., KovacsR.J., KingeryJ.R., Antimicrobial agents and chemotherapy. . 2012,第8期

机译：与静脉注射奎尼丁有关的耐药性疟疾或杆状杆菌病，存在QT间期延长和扭转性高发的高风险
2. Azithromycin, cardiovascular risks, QTc interval prolongation, torsade de pointes , and regulatory issues: A narrative review based on the study of case reports [J] . Jules C. Hancox, Mehrul Hasnain, W. Victor R. Vieweg, Therapeutic advances in infectious disease. . 2013,第5期

机译：阿奇霉素，心血管疾病风险，QTc间隔延长，扭转性扭转性瘫痪和监管问题：基于病例报告的叙述性综述
3. Intracoronary Acetylcholine-Induced Prolongation of the QT Interval and Torsade des Pointes in Long QT Interval Syndrome [J] . Yoshifusa AIZAWA, Taku MATSUBARA, Koutarou HIGUCHI, Japanese heart journal . 1994,第5期

机译：冠状动脉内乙酰胆碱引起的QT间隔延长和长QT间隔综合征中的扭转型室间隔延长
4. Static and dynamic electrocardiographic patterns preceding torsades de pointes in the acquired and congenital long QT syndrome [C] . Couderc J.P., Xia J., Xu X., 2010 Computers in Cardiology . 2010

机译：扭转和扭转先天性和先天性长QT综合征之前的静态和动态心电图模式
5. Potential mechanisms for drug-induced prolongation of QT interval and genesis of torsades de pointes evaluated in the failing rabbit heart. [D] . Kijtawornrat, Anusak. 2007

机译：在衰竭的心脏中评估了药物引起的QT间隔延长和扭转性扭转的潜在机制。
6. High Risk of QT Interval Prolongation and Torsades de Pointes Associated with Intravenous Quinidine Used for Treatment of Resistant Malaria or Babesiosis [O] . Heather A. Wroblewski, Richard J. Kovacs, Joanna R. Kingery, 2012

机译：QT间期延长的高风险和与静脉注射奎尼丁有关的点扭转性眼病用于抗药性疟疾或杆状杆菌病
7. Erythromycin, QTc interval prolongation, and torsade de pointes: Case reports, major risk factors and illness severity [O] . Jules C. Hancox, Mehrul Hasnain, W. Victor R. Vieweg, 2014

机译：红霉素，QTC间隔延长和躯干DE指向：案例报告，主要危险因素和疾病严重程度
8. Q-T-Interval in Relatie tot Totale, Cardiovasculaire en IschaemischeHartziektesterfte: Een Prospektieve Studie onder Amsterdamse Ambtenaren (QT-Interval Prolongation Predicts Cardiovascular Mortality in the General Population) [R] . Meppelink, P. 1990

机译：Q-T-Interval in Relatie tot Totale，Cardiovasculaire en IschaemischeHartziektesterfte：Een prospektieve studie onder amsterdamse ambtenaren（QT-Interval延长预测一般人群中的心血管死亡率）

High risk of QT interval prolongation and torsades de pointes associated with intravenous quinidine used for treatment of resistant malaria or babesiosis

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