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首页> 外文期刊>Antimicrobial agents and chemotherapy. >Novel synthetic antimicrobial peptides against Streptococcus mutans.
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Novel synthetic antimicrobial peptides against Streptococcus mutans.

机译：新型抗变形链球菌的合成抗菌肽。

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Streptococcus mutans, a common oral pathogen and the causative agent of dental caries, has persisted and even thrived on the tooth surface despite constant removal and eradication efforts. In this study, we generated a number of synthetic antimicrobial peptides against this bacterium via construction and screening of several structurally diverse peptide libraries where the hydrophobicity and charge within each library was varied incrementally in order to generate a collection of peptides with different biochemical characteristics. From these libraries, we identified multiple peptides with robust killing activity against S. mutans. To further improve their effectiveness, the most bactericidal peptides from each library were synthesized together as one molecule, in various combinations, with and without a flexible peptide linker between each antimicrobial region. Many of these "fusion" peptides had enhanced killing activities in comparison with those of the original nonconjoined molecules. The results presented here illustrate that small libraries of biochemically constrained peptides can be used to generate antimicrobial peptides against S. mutans, several of which may be likely candidates for the development of anticaries agents.
机译：尽管不断地进行清除和根除工作，变形链球菌是一种常见的口腔病原体和龋齿的病因，在牙齿表面仍然存在，甚至蓬勃发展。在这项研究中，我们通过构建和筛选几个结构多样的肽文库，生成了许多针对该细菌的合成抗菌肽，其中每个文库中的疏水性和电荷逐渐变化，以生成具有不同生化特征的肽集合。从这些文库中，我们鉴定出了对变形链球菌具有强大杀伤活性的多种肽。为了进一步提高其有效性，将每个文库中最具杀菌力的肽以一种分子的形式合成为各种组合，在每个抗菌区域之间带有或不带有柔性肽接头。与原始非结合分子相比，这些“融合”肽中的许多具有增强的杀伤活性。此处显示的结果说明，生化约束肽的小型文库可用于生成抗变形链球菌的抗菌肽，其中一些可能是抗龋药开发的候选对象。

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