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首页> 外文期刊>Antimicrobial agents and chemotherapy. >Effect of rifampin on production of inflammatory mediators in HepG2 liver epithelial cells.
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Effect of rifampin on production of inflammatory mediators in HepG2 liver epithelial cells.

机译：利福平对HepG2肝上皮细胞炎性介质产生的影响。

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摘要

Rifampin, a potent antibacterial agent, is one of the main drugs used in the treatment of mycobacterial infections. Hepatotoxicity is a well-documented adverse event. The aim of this study was to investigate the effect of rifampin on the production of inflammatory mediators in human epithelial HepG2 liver cells in the absence or presence of proinflammatory cytokines. Incubation of HepG2 cells with a cytokine mix plus rifampin was associated with a significant dose-dependent increase in the production of nitric oxide compared to incubation with the cytokine mix alone (P < 0.05) as well as with an increase in inducible nitric oxide synthase protein and mRNA expression. Rifampin significantly increased the secretion of interleukin 8 (IL-8) in both untreated cells (P < 0.001) and cytokine-treated cells (P < 0.006). An array screening assay revealed that rifampin stimulated the production of IL-1beta and gamma interferon-induced protein-10 (IP-10) in untreated cells and increased the secretion of RANTES in cytokine-treated cells. Together, these results indicate that rifampin may exert proinflammatory effects on liver cells.
机译：利福平是一种有效的抗菌剂，是用于治疗分枝杆菌感染的主要药物之一。肝毒性是有据可查的不良事件。这项研究的目的是研究在缺乏或存在促炎细胞因子的情况下，利福平对人上皮HepG2肝细胞中炎性介质产生的影响。与仅与细胞因子混合物孵育相比，将HepG2细胞与细胞因子混合物加利福平一起孵育与一氧化氮的产量显着剂量依赖性增加（P <0.05）以及诱导型一氧化氮合酶蛋白的增加有关和mRNA表达。利福平显着增加了未经处理的细胞（P <0.001）和经细胞因子处理的细胞（P <0.006）中白介素8（IL-8）的分泌。阵列筛选测定显示，利福平刺激了未经处理的细胞中IL-1β和γ干扰素诱导的蛋白10（IP-10）的产生，并增加了经细胞因子处理的细胞中RANTES的分泌。总之，这些结果表明利福平可能对肝细胞发挥促炎作用。

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