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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Progesterone induces BRCA1 mRNA decrease, cell cycle alterations and apoptosis in the MCF7 breast cancer cell line.
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Progesterone induces BRCA1 mRNA decrease, cell cycle alterations and apoptosis in the MCF7 breast cancer cell line.

机译：孕酮诱导MCF7乳腺癌细胞株BRCA1 mRNA降低，细胞周期改变和凋亡。

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摘要

BACKGROUND: Inherited mutations of the BRCA1 gene are responsible for hereditary breast and ovarian cancer syndrome. However, little is known of how disruption of BRCA1 functions preferentially increases cancer risk in hormone-dependent organs. We aimed to study whether BRCA1 was regulated by progesterone in the MCF7 breast cancer cell line. MATERIALS AND METHODS: MCF7 breast cancer cells were incubated with 10(-4) or 10(-10) M progesterone for 24 or 48 hours. BRCA1 expression, proliferation and apoptosis were analysed. RESULTS: 10(-4) M progesterone decreased cell proliferation, cell cycle progression and induced apoptosis. In addition, BRCA1 and cyclin A mRNA decreased. In contrast, none of these effects were observed in MCF7 cells incubated with 10(-10) M progesterone. CONCLUSION: The down-regulation of BRCA1 in MCF7 cells incubated with 10(-4) M progesterone seems to be a consequence of cell cycle alterations rather than a direct effect of the hormone on BRCA1.
机译：背景：BRCA1基因的遗传突变是遗传性乳腺癌和卵巢癌综合征的原因。然而，很少有人知道BRCA1功能的破坏如何优先增加激素依赖性器官中的癌症风险。我们旨在研究BRCA1在MCF7乳腺癌细胞系中是否受孕激素调节。材料与方法：将MCF7乳腺癌细胞与10（-4）或10（-10）M孕酮孵育24或48小时。分析BRCA1的表达，增殖和凋亡。结果：10（-4）M孕酮降低细胞增殖，细胞周期进程和诱导细胞凋亡。此外，BRCA1和细胞周期蛋白A mRNA下降。相反，在与10（-10）M孕酮孵育的MCF7细胞中未观察到这些作用。结论：与10（-4）M孕酮一起孵育的MCF7细胞中BRCA1的下调似乎是细胞周期改变的结果，而不是激素对BRCA1的直接作用。

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