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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >B-cell differentiation, apoptosis and proliferation in diffuse large B-cell lymphomas.
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B-cell differentiation, apoptosis and proliferation in diffuse large B-cell lymphomas.

机译：弥漫性大B细胞淋巴瘤中的B细胞分化，凋亡和增殖。

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摘要

Diffuse large B-cell lymphomas (DLBCL) represent the most common type of adult non-Hodgkin's lymphomas in Western countries and are characterized by heterogeneous clinical, histological, immunophenotypic and genetic features. Recent investigations using cDNA and oligonucleotide microarrays have identified molecularly distinct groups of DLBCL with respect to the B-cell differentiation gene expression profile: the germinal center (GC) B-cell-like DLBCL, the activated B-cell-like DLBCL and the type 3 DLBCL. The GC B-cell-like DLBCL were characterized by the expression of genes of the normal GC B-cells, the activated B-cell-like DLBCL were characterized by the expression of genes that are normally induced luring in vitro activation of peripheral blood B-cells, while the type 3 DLBCL did not express either set of genes at a high level. Patients with GC B-cell-like DLBCL had more favorable clinical outcome than those with activated B-cell-like or type 3 DLBCL. Immunohistochemical studies have shown that the bc16/CD10/MUM1/CD138 B-cell differentiation immunophenotypes are prognostically relevant and may predict the cDNA classification in a sizable fraction of DLBCL. In the last few years, there has been accumulating molecular and immunohistochemical evidence indicating links between B-cell differentiation gene expression profiles and expression of apoptosis and cell cycle-associated genes in DLBCL. The present review summarizes data with respect to the relationships between B-cell differentiation, apoptosis and proliferation in DLBCL.
机译：弥漫性大B细胞淋巴瘤（DLBCL）代表西方国家最常见的成人非霍奇金淋巴瘤类型，并具有异质的临床，组织学，免疫表型和遗传学特征。最近，使用cDNA和寡核苷酸微阵列进行的研究就B细胞分化基因的表达谱确定了DLBCL的分子不同组：生发中心（GC）B细胞样DLBCL，激活的B细胞样DLBCL和类型3 DLBCL。 GC B细胞样DLBCL的特征在于正常GC B细胞的基因表达，活化的B细胞样DLBCL的特征在于正常诱导体外血液B激活的基因的表达。 -细胞，而3型DLBCL却没有高水平表达任何一组基因。具有GC B细胞样DLBCL的患者比具有活化B细胞样或3型DLBCL的患者具有更好的临床预后。免疫组织化学研究表明，bc16 / CD10 / MUM1 / CD138 B细胞分化免疫表型与预后相关，并可预测相当大一部分DLBCL的cDNA分类。在过去的几年中，越来越多的分子和免疫组织化学证据表明，DLBCL中B细胞分化基因表达谱与凋亡和细胞周期相关基因的表达之间存在联系。本综述总结了有关DLBCL中B细胞分化，凋亡和增殖之间关系的数据。

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