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首页> 外文期刊>Antimicrobial agents and chemotherapy. >Effect of silver content on the structure and antibacterial activity of silver-doped phosphate-based glasses.
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Effect of silver content on the structure and antibacterial activity of silver-doped phosphate-based glasses.

机译：银含量对掺银磷酸盐基玻璃的结构和抗菌活性的影响。

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Staphylococcus aureus can cause a range of diseases, such as osteomyelitis, as well as colonize implanted medical devices. In most instances the organism forms biofilms that not only are resistant to the body's defense mechanisms but also display decreased susceptibilities to antibiotics. In the present study, we have examined the effect of increasing silver contents in phosphate-based glasses to prevent the formation of S. aureus biofilms. Silver was found to be an effective bactericidal agent against S. aureus biofilms, and the rate of silver ion release (0.42 to 1.22 mug.mm(-2).h(-1)) from phosphate-based glass was found to account for the variation in its bactericidal effect. Analysis of biofilms by confocal microscopy indicated that they consisted of an upper layer of viable bacteria together with a layer ( approximately 20 mum) of nonviable cells on the glass surface. Our results showed that regardless of the silver contents in these glasses (10, 15, or 20 mol%) the silver exists in its +1 oxidation state, which is known to be a highly effective bactericidal agent compared to that of silver in other oxidation states (+2 or +3). Analysis of the glasses by (31)P nuclear magnetic resonance imaging and high-energy X-ray diffraction showed that it is the structural rearrangement of the phosphate network that is responsible for the variation in silver ion release and the associated bactericidal effectiveness. Thus, an understanding of the glass structure is important in interpreting the in vitro data and also has important clinical implications for the potential use of the phosphate-based glasses in orthopedic applications to deliver silver ions to combat S. aureus biofilm infections.
机译：金黄色葡萄球菌可引起多种疾病，例如骨髓炎，以及使植入的医疗器械定植。在大多数情况下，生物体形成的生物膜不仅对人体的防御机制有抵抗力，而且对抗生素的敏感性降低。在本研究中，我们检查了增加磷酸盐基玻璃中银含量对防止金黄色葡萄球菌生物膜形成的影响。发现银是对抗金黄色葡萄球菌生物膜的有效杀菌剂，并且发现磷酸盐基玻璃中银离子的释放速率（0.42至1.22 mug.mm（-2）.h（-1））占了杀菌效果的变化。通过共聚焦显微镜对生物膜的分析表明，它们由玻璃表面上的活细菌的上层和无活细胞的一层（约20微米）组成。我们的结果表明，不管这些玻璃中的银含量（10、15或20 mol％），银都以+1氧化态存在，与其他氧化法中的银相比，银是一种高效的杀菌剂。状态（+2或+3）。通过（31）P核磁共振成像和高能X射线衍射对玻璃进行分析，结果表明，磷酸盐网络的结构重排是造成银离子释放变化和相关杀菌效果的原因。因此，对玻璃结构的理解在解释体外数据中很重要，并且对于整形外科应用中磷酸盐基玻璃的潜在用途以传递银离子以对抗金黄色葡萄球菌生物膜感染也具有重要的临床意义。

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