Structure-function correlations of two highly conserved motifs in Saccharomyces cerevisiae squalene epoxidase.

Ruckenstuhl C; Poschenel A; Possert R; Baral PK; Gruber K; Turnowsky F

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Structure-function correlations of two highly conserved motifs in Saccharomyces cerevisiae squalene epoxidase.

机译：酿酒酵母角鲨烯环氧酶中两个高度保守的基序的结构功能相关性。

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Saccharomyces cerevisiae squalene epoxidase contains two highly conserved motifs, 1 and 2, of unknown function. Amino acid substitutions in both regions reduce enzyme activity and/or alter allylamine sensitivity. In the homology model, these motifs flank the flavin adenine dinucleotide cofactor and form part of the interface between cofactor and substrate binding domains.

机译：酿酒酵母角鲨烯环氧酶包含两个高度保守的功能未知的基序1和2。两个区域中的氨基酸取代都会降低酶的活性和/或改变烯丙胺的敏感性。在同源模型中，这些基序位于黄素腺嘌呤二核苷酸辅因子的侧面，并形成辅因子和底物结合结构域之间的界面的一部分。

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《Antimicrobial agents and chemotherapy.》 |2008年第4期|共4页
作者
Ruckenstuhl C; Poschenel A; Possert R; Baral PK; Gruber K; Turnowsky F;
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正文语种 eng
中图分类治疗学;
关键词
squalene monooxygenase (2; 3-epoxidizing); Saccharomyces cerevisiae; physiological aspects; 酵母菌; 酿酒;

机译：squalene monooxygenase (2;3-epoxidizing);Saccharomyces cerevisiae;physiological aspects;酵母菌;酿酒;

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1. Structure-function correlations of two highly conserved motifs in Saccharomyces cerevisiae squalene epoxidase. [J] . Ruckenstuhl C, Poschenel A, Possert R, Antimicrobial agents and chemotherapy. . 2008,第4期

机译：酿酒酵母角鲨烯环氧酶中两个高度保守的基序的结构功能相关性。
2. Investigation of the role of a conserved glycine motif in the Saccharomyces cerevisiae xylose reductase [J] . Chu BC, Lee H Current Microbiology: An International Journal . 2006,第2期

机译：保守的甘氨酸基序在酿酒酵母木糖还原酶中的作用研究
3. A protein containing conserved RNA-recognition motifs is associated with ribosomal subunits in Saccharomyces cerevisiae [J] . John L. Woolford Jr, Tracy L. Ripmaster Nucleic acids research . 1993,第14期

机译：含有保守的RNA识别基序的蛋白质与酿酒酵母中的核糖体亚基相关
4. Structure-function relationships of the di/tri-peptide transporter of the yeast Saccharomyces cerevisiae:a model system for studying substrate recognition and regulation of membrane proteins involved in peptide transport [C] . Jeffrey M.Becker, Melinda Hauser, Steven Minkin International Peptide Symposium;European Peptide Symposium . 2005

机译：酵母酿酒酵母的DI /三肽转运蛋白的结构函数关系：一种研究底物识别的模型系统和肽运输中膜蛋白的调节
5. Regulatory analysis of squalene synthase (ERG9) from Saccharomyces cerevisiae and the cloning and characterization of the C-4 sterol methyloxidase gene (ERG25) from Candida albicans. [D] . Kennedy, Matthew Adam. 2000

机译：来自酿酒酵母的角鲨烯合酶（ERG9）的调控分析以及来自白色念珠菌的C-4固醇甲基氧化酶基因（ERG25）的克隆和表征。
6. Structure-Function Correlations of Two Highly Conserved Motifs in Saccharomyces cerevisiae Squalene Epoxidase [O] . Christoph Ruckenstuhl, Andrea Poschenel, Reinhard Possert, 2008

机译：酿酒酵母角鲨烯环氧酶中两个高度保守的基序的结构功能相关性
7. Structure-Function Correlations of Two Highly Conserved Motifs in Saccharomyces cerevisiae Squalene Epoxidase▿ [O] . Ruckenstuhl, Christoph, Poschenel, Andrea, Possert, Reinhard, 2008

机译：酿酒酵母角鲨烯环氧酶中两个高度保守的基序的结构功能相关性

Structure-function correlations of two highly conserved motifs in Saccharomyces cerevisiae squalene epoxidase.

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