Fluoroquinolone resistance in anaerobic bacteria following exposure to levofloxacin, trovafloxacin, and sparfloxacin in an in vitro pharmacodynamic model.

Ross GH; Wright DH; Hovde LB; Peterson ML; Rotschafer JC

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Fluoroquinolone resistance in anaerobic bacteria following exposure to levofloxacin, trovafloxacin, and sparfloxacin in an in vitro pharmacodynamic model.

机译：在体外药效学模型中，暴露于左氧氟沙星，曲伐沙星和司帕沙星的厌氧菌对氟喹诺酮耐药。

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This investigation explored pharmacodynamic characteristics of fluoroquinolones against Bacteroides thetaiotamicron and the potential for development of resistance. An in vitro model was used to generate kill curves with three fluoroquinolones at various area under the concentration-time curve (AUC)/MIC ratios. Concentration-independent killing was observed. Increases in MICs were noted following exposure to fluoroquinolones at AUC/MIC ratios of 6 to 14.

机译：这项研究探讨了氟喹诺酮类药物对拟杆菌（Theactotaides thetaiotamicron）的药效学特征以及产生耐药性的潜力。在浓度-时间曲线（AUC）/ MIC比下，使用体外模型生成在不同区域具有三种氟喹诺酮类的杀灭曲线。观察到浓度无关的杀灭。在以6:14的AUC / MIC比暴露于氟喹诺酮类药物后，MIC有所增加。

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《Antimicrobial agents and chemotherapy.》 |2001年第7期|共5页
作者
Ross GH; Wright DH; Hovde LB; Peterson ML; Rotschafer JC;
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正文语种 eng
中图分类治疗学;
关键词
Anti-Infective Agents; Fluoroquinolone; Bacteroides; Naphthyridines; sparfloxacin; 抗感染药; 氟喹诺酮; 拟杆菌属;

机译：Anti-Infective Agents;Fluoroquinolone;Bacteroides;Naphthyridines;sparfloxacin;抗感染药;氟喹诺酮;拟杆菌属;

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1. Fluoroquinolone resistance in anaerobic bacteria following exposure to levofloxacin, trovafloxacin, and sparfloxacin in an in vitro pharmacodynamic model. [J] . Ross GH, Wright DH, Hovde LB, Antimicrobial agents and chemotherapy. . 2001,第7期

机译：在体外药效学模型中，暴露于左氧氟沙星，曲伐沙星和司帕沙星的厌氧菌对氟喹诺酮耐药。
2. Pharmacodynamics of trovafloxacin and levofloxacin against Bacteroides fragilis in an in vitro pharmacodynamic model. [J] . Peterson ML, Hovde LB, Wright DH, Antimicrobial agents and chemotherapy. . 2002,第1期

机译：在体外药效学模型中，Trovafloxacin和levofloxacin对抗脆弱类杆菌的药效学。
3. Phenotypic resistance of Staphylococcus aureus, selected Enterobacteriaceae, and Pseudomonas aeruginosa after single and multiple in vitro exposures to ciprofloxacin, levofloxacin, and trovafloxacin. [J] . Gilbert DN, Kohlhepp SJ, Slama KA, Antimicrobial agents and chemotherapy. . 2001,第3期

机译：单次或多次体外暴露于环丙沙星，左氧氟沙星和曲伐沙星后，金黄色葡萄球菌，选定的肠杆菌科和铜绿假单胞菌的表型抗性。
4. Characteristics and Mechanisms of Mercury Resistance of the Anaerobic Bacteria Isolated from Mercury Polluted Sea Bottom Sediment [C] . GINRO ENDO, MASARU NARITA International symposium of the International Society for environmental biodiagnostics . 2001

机译：汞污染海底沉积物中厌氧菌汞抗性的特征及机制
5. Design and synthesis of fluoroquinolones to overcome resistance in bacteria. [D] . Williamson, Benjamin Howard. 2015

机译：设计和合成氟喹诺酮类药物以克服细菌的耐药性。
6. Note: Fluoroquinolone Resistance in Anaerobic Bacteria following Exposure to Levofloxacin Trovafloxacin and Sparfloxacin in an In Vitro Pharmacodynamic Model [O] . Gigi H. Ross, David H. Wright, Laurie Baeker Hovde, 2001

机译：注意：在体外药效学模型中暴露于左氧氟沙星曲伐沙星和司巴沙星后厌氧细菌中的氟喹诺酮耐药性
7. Fluoroquinolone Resistance in Anaerobic Bacteria following Exposure to Levofloxacin, Trovafloxacin, and Sparfloxacin in an In Vitro Pharmacodynamic Model [O] . Ross, Gigi H., Wright, David H., Hovde, Laurie Baeker, 2001

机译：在体外药效学模型中暴露于左氧氟沙星，曲伐沙星和司巴沙星后厌氧细菌的氟喹诺酮耐药性

Fluoroquinolone resistance in anaerobic bacteria following exposure to levofloxacin, trovafloxacin, and sparfloxacin in an in vitro pharmacodynamic model.

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