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首页> 外文期刊>International journal of pharmacokinetics. >Opposite effects of acute kidney injury on pharmacokinetics of renally and hepatobiliary excreted drugs
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Opposite effects of acute kidney injury on pharmacokinetics of renally and hepatobiliary excreted drugs

机译：相反的急性肾损伤的影响药物动力学的肾和肝胆管的排泄的药物

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Aim: Influence of cisplatin-induced acute kidney injury (AKI) on the pharmacokinetics of ciprofloxacin/fasiglifam was investigated. Methods: Normal and AKI rats received oral/intravenous doses of 5 and 1 mg/kg for ciprofloxacin and 3 and 1 mg/kg for fasiglifam, respectively. Plasma samples were subjected to LC-MS/MS analysis, followed by pharmacokinetic analysis. Liver S-9 fractions were used for stability assessment. Results: Regardless of intravenous/oral dosing, ciprofloxacin concentrations increased in AKI relative to normal rats. Oral bioavailability of ciprofloxacin was 79/24% in AKI/normal rats. With fasiglifam, pharmacokinetics was not altered in AKI versus normal rats after intravenous dosing. However, oral dosing showed 25-36% lower exposure in AKI rats. Liver S-9 fractions obtained from AKI/normal rats showed metabolic stability. Conclusion: AKI rats showed enhanced/decreased bioavailability of ciprofloxacin/fasiglifam.
机译：目的:cisplatin-induced急性肾功能的影响受伤(阿基)的药物动力学环丙沙星/ fasiglifam调查。方法:正常和阿基老鼠了口服或静脉注射剂量的5和1毫克/公斤环丙沙星和fasiglifam 3和1毫克/公斤,分别。质/ MS分析,其次是药代动力学分析。稳定性评估。静脉或口服剂量,环丙沙星阿基相对于浓度增加正常的老鼠。环丙沙星在阿基79/24% /正常的老鼠。fasiglifam,药物动力学并没有改变阿基与正常大鼠静脉注射给药后。然而,口服剂量显示25 - 36%低风险在阿基老鼠。阿基/正常的老鼠显示代谢稳定性。结论:两组大鼠显示增强/下降环丙沙星/ fasiglifam的生物利用度。

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