Mononuclear and polymorphonuclear leukocyte dispositions of clarithromycin and azithromycin in AIDS patients requiring Mycobacterium avium complex prophylaxis.

Bui KQ; McNabb J; Li C; Nightingale CH; Nicolau DP

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Mononuclear and polymorphonuclear leukocyte dispositions of clarithromycin and azithromycin in AIDS patients requiring Mycobacterium avium complex prophylaxis.

机译：需要预防鸟分枝杆菌的爱滋病患者中，克拉霉素和阿奇霉素的单核和多形核白细胞配置。

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The intracellular dispositions of clarithromycin and azithromycin in AIDS patients requiring Mycobacterium avium complex (MAC) prophylaxis were studied. The dispositions of both drugs in mononuclear and polymorphonuclear leukocytes were markedly different. Our data support the proven efficacy of these agents for MAC prophylaxis since clarithromycin and azithromycin displayed sustained intracellular concentrations which exceeded their MICs for MAC throughout the dosing periods.

机译：研究了需要预防鸟分枝杆菌复合物（MAC）的艾滋病患者中克拉霉素和阿奇霉素的细胞内配置。两种药物在单核白细胞和多形核白细胞中的配置都有明显的不同。由于克拉霉素和阿奇霉素显示出持续的细胞内浓度，在整个给药期间超过了其MIC的MIC，因此我们的数据支持了这些药物对MAC预防的经证实的功效。

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《Antimicrobial agents and chemotherapy.》 |1999年第9期|共3页
作者
Bui KQ; McNabb J; Li C; Nightingale CH; Nicolau DP;
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正文语种 eng
中图分类治疗学;
关键词
Acquired Immunodeficiency Syndrome; Antibiotics; Macrolide; Azithromycin; 获得性免疫缺陷综合征; 抗生素; 大环内酯; 叠氮红霉素; 6-O-甲基红霉素; 白细胞; 单核;

机译：Acquired Immunodeficiency Syndrome;Antibiotics;Macrolide;Azithromycin;获得性免疫缺陷综合征;抗生素;大环内酯;叠氮红霉素;6-O-甲基红霉素;白细胞;单核;

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专利

1. Mononuclear and polymorphonuclear leukocyte dispositions of clarithromycin and azithromycin in AIDS patients requiring Mycobacterium avium complex prophylaxis. [J] . Bui KQ, McNabb J, Li C, Antimicrobial agents and chemotherapy. . 1999,第9期

机译：需要预防鸟分枝杆菌的爱滋病患者中，克拉霉素和阿奇霉素的单核和多形核白细胞配置。
2. Azithromycin as treatment for disseminated Mycobacterium avium complex in AIDS patients. [J] . Koletar SL, Berry AJ, Cynamon MH, Antimicrobial agents and chemotherapy. . 1999,第12期

机译：阿奇霉素治疗艾滋病患者弥散性鸟分枝杆菌复合物。
3. PP-148 Simultaneous disseminated mycobacterium avium complex (MAC) and pulmonary cryptococcosis in an AIDS patient: presentation of immune reconstitution inflammatory syndrome (IRIS) requiring corticosteroid therapy [J] . Azadeh Nasseh, Baya Omidnia, Ladan Ahmadi International journal of infectious diseases : . 2009,第Supplementa1期

机译：PP-148艾滋病患者同时传播鸟分枝杆菌复合物（MAC）和肺隐球菌病：需要皮质类固醇疗法的免疫重建炎症综合症（IRIS）表现
4. In Vitro Migration Study Of Human Polymorphonuclear And Mononuclear Leukocytes In A Dc Magnetic Field [C] . Feng, D., Beard, Engineering in Medicine and Biology Society, 1990., Proceedings of the Twelfth Annual International Conference of the IEEE . 1990

机译：Dc磁场中人多形核和单核白细胞的体外迁移研究
5. CXCR2-expressing polymorphonuclear leukocytes are required for the development of experimental autoimmune encephalomyelitis [D] . Carlson, Thaddeus John. 2007

机译：表达CXCR2的多形核白细胞是实验性自身免疫性脑脊髓炎的发展所必需的
6. Note: Mononuclear and Polymorphonuclear Leukocyte Dispositions of Clarithromycin and Azithromycin in AIDS Patients Requiring Mycobacterium avium Complex Prophylaxis [O] . Khanh Q. Bui, JoCarol McNabb, Chonghua Li, 1999

机译：注意：需要鸟分枝杆菌复合物预防的艾滋病患者中克拉霉素和阿奇霉素的单核和多形核白细胞分布
7. Mycobacterium avium complex (MAC) isolated from AIDS patients and the criteria required for its implication in disease Complexo Mycobacterium avium (MAC) isolado de pacientes com AIDS e os critérios exigidos para sua implicação em doença [O] . David Jamil Hadad, Maria Cecília de Almeida Palhares, Anna Luiza Nunes Placco, 1995

机译：从艾滋病患者分离的鸟分枝杆菌复合物（MAC）及其对疾病的影响所需的标准从艾滋病患者分离的鸟分枝杆菌复合物（MAC）及其对疾病的影响所需的标准

Mononuclear and polymorphonuclear leukocyte dispositions of clarithromycin and azithromycin in AIDS patients requiring Mycobacterium avium complex prophylaxis.

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