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首页> 外文期刊>Antimicrobial agents and chemotherapy. >Pharmacodynamic modeling of in vitro activity of marbofloxacin against Escherichia coli strains.
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Pharmacodynamic modeling of in vitro activity of marbofloxacin against Escherichia coli strains.

机译：马波沙星抗大肠杆菌菌株体外活性的药效学模拟。

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A mathematical pharmacodynamic model was developed to describe the bactericidal activity of marbofloxacin against Escherichia coli strains with reduced susceptibility levels (determined using MICs) under optimal and intestinal growth conditions. Model parameters were estimated using nonlinear least-square curve-fitting procedures for each E. coli strain. Parameters related to bactericidal activity were subsequently analyzed using a maximum-effect (E(max)) model adapted to account for a direct and a delayed effect. While net growth rates did not vary significantly with strain susceptibility, culture medium had a major effect. The bactericidal activity of marbofloxacin was closely associated with the concentration and the duration of exposure of the bacteria to the antimicrobial agent. The value of the concentration inducing a half-maximum effect (C(50)) was highly correlated with MIC values (R(2) = 0.87 and R(2) = 0.94 under intestinal and optimal conditions, respectively). Our model reproduced the time-kill kinetics with good accuracy (R(2) of >0.90) and helped explain observed regrowth.
机译：建立了数学药效学模型，以描述在最佳和肠道生长条件下，马波沙星对敏感性降低的大肠杆菌菌株的杀菌活性（使用MIC确定）。使用非线性最小二乘曲线拟合程序对每个大肠杆菌菌株估计模型参数。随后使用适于解释直接作用和延迟作用的最大作用（E（max））模型分析与杀菌活性有关的参数。虽然净增长率没有随菌株的敏感性而显着变化，但培养基具有主要作用。马波沙星的杀菌活性与细菌暴露于抗微生物剂的浓度和持续时间密切相关。诱导半数最大效应的浓度值（C（50））与MIC值高度相关（分别在肠道和最佳条件下R（2）= 0.87和R（2）= 0.94）。我们的模型以高精确度（R（2）> 0.90）重现了时间杀灭动力学，并有助于解释观察到的再生长。

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