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首页> 外文期刊>Antioxidants and redox signalling >Emerging role of carbon monoxide in physiologic and pathophysiologic states.
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Emerging role of carbon monoxide in physiologic and pathophysiologic states.

机译:一氧化碳在生理和病理生理状态中的新兴作用。

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The discovery of nitric oxide in the 1980s unraveled the novel concept then that an endogenous production of a gaseous substance such as nitric oxide can impart critical physiologic functions in a variety of biological and pathological processes. Interestingly though, we have known for a longer period of time that there exists another gaseous molecule, carbon monoxide (CO), that can be generated endogenously. The heme oxygenase enzyme system generates the majority, if not, all of the endogenous CO. Accumulating data in recent years have lent an intriguing supposition that we need to regard CO beyond the old paradigm that it imparts only toxicity and lethality to organisms. Instead, we need to consider CO, at low physiologic concentration, to play critical physiologic roles in various pathophysiologic states. This forum will review this double-edge sword of CO.
机译:一氧化氮在1980年代的发现揭开了这一新概念的面纱,即内源性生产气态物质(如一氧化氮)可以在各种生物学和病理学过程中赋予重要的生理功能。但是,有趣的是,我们已经较长时间地知道存在另一种气体分子,一氧化碳(CO),它可以内生地产生。血红素加氧酶系统可产生大部分(如果不是)所有内源性CO。近年来积累的数据提出了一个有趣的假设,即我们需要将CO视为一种仅对生物体赋予毒性和致死性的旧范式,而不是它。相反,我们需要考虑低生理浓度的CO在各种病理生理状态下发挥关键的生理作用。该论坛将审查CO的这把双刃剑。

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