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首页> 外文期刊>Antimicrobial agents and chemotherapy. >Integron- and carbenicillinase-mediated reduced susceptibility to amoxicillin-clavulanic acid in isolates of multidrug-resistant Salmonella enterica serotype typhimurium DT104 from French patients.
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Integron- and carbenicillinase-mediated reduced susceptibility to amoxicillin-clavulanic acid in isolates of multidrug-resistant Salmonella enterica serotype typhimurium DT104 from French patients.

机译：整合素和羧苄青霉素酶介导的法国患者多重耐药沙门氏菌鼠伤寒沙门氏菌DT104分离株对阿莫西林-克拉维酸的敏感性降低。

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摘要

Fifty-seven Salmonella enterica serotype Typhimurium (S. typhimurium) isolates were collected from human patients in two French hospitals, Hopital Antoine Beclere (Clamart, France) and Hopital Bicetre (Le Kremlin-Bicetre, France), between 1996 and 1997. Thirty of them (52 percent) were resistant to amino-, carbeni-, and ureidopenicillins, had reduced susceptibility to amoxicillin-clavulanic acid, were susceptible to cephalothin, and were resistant to sulfonamides, streptomycin, chloramphenicol, and tetracyclines. All these strains possessed a blaPSE-1-like gene and were of phage type DT104. Ten of them were studied in more detail, which revealed that blaPSE-1 is located on the variable region of a class 1 integron. This integron was found to be chromosomally located, as was another class 1 integron containing aadA2, a streptomycin-spectinomycin resistance gene. The reduced susceptibility to amoxicillin-clavulanic acid (and to ticarcillin-clavulanic acid) may result from the high level of hydrolysis of the beta-lactam rather than to the clavulanic acid resistance properties of PSE-1 in these clonally related S. typhimurium isolates.
机译：在1996年至1997年之间，从两家法国医院Hopital Antoine Beclere（法国Clamart）和Hopital Bicetre（法国Le Kremlin-Bicetre）的人类患者中收集了57株肠炎沙门氏菌血清型鼠伤寒沙门氏菌（鼠伤寒沙门氏菌）分离株。它们（52％）对氨基，卡宾和脲醛青霉素具有抗性，对阿莫西林-克拉维酸的敏感性降低，对头孢菌素敏感，对磺酰胺，链霉素，氯霉素和四环素类药物具有抗性。所有这些菌株都具有blaPSE-1样基因，并且属于噬菌体DT104型。对其中的十个进行了更详细的研究，发现blaPSE-1位于1类整合子的可变区上。发现该整合子位于染色体上，而另一个含有链霉素-壮观霉素抗性基因aadA2的1类整合子也位于染色体上。对阿莫西林-克拉维酸（和替卡西林-克拉维酸）的敏感性降低可能是由于β-内酰胺的高水解而不是这些克隆相关鼠伤寒沙门氏菌分离物中PSE-1的抗克拉维酸性质所致。

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