Novel apramycin resistance gene apmA in bovine and porcine methicillin-resistant Staphylococcus aureus ST398 isolates.

Fessler AT; Kadlec K; Schwarz S

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Novel apramycin resistance gene apmA in bovine and porcine methicillin-resistant Staphylococcus aureus ST398 isolates.

机译：牛和猪耐甲氧西林金黄色葡萄球菌ST398分离物中的新型阿霉素抗性基因apmA。

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A novel apramycin resistance gene, apmA, was detected on the ca.-40-kb resistance plasmid pAFS11 from bovine methicillin-resistant Staphylococcus aureus (MRSA) of sequence type 398 (ST398). The apmA gene coded for a protein of 274 amino acids that was related only distantly to acetyltransferases involved in chloramphenicol or streptogramin A resistance. NsiI deletion of apmA resulted in a 16- to 32-fold decrease in the apramycin MICs. An apmA-specific PCR identified this gene in one additional bovine and four porcine MRSA ST398 isolates.

机译：在约398 bp的耐甲氧西林金黄色葡萄球菌（MRSA）的约-40 kb耐药质粒pAFS11上检测到一个新的阿霉素抗性基因apmA（ST398）。 apmA基因编码的274个氨基酸的蛋白质仅与参与氯霉素或链霉菌素A抗性的乙酰基转移酶有很远的关系。 ApmA的NsiI缺失导致阿普霉素MIC降低16到32倍。 apmA特异性PCR在另一种牛和四种猪MRSA ST398分离株中鉴定了该基因。

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《Antimicrobial agents and chemotherapy.》 |2011年第1期|共3页
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Fessler AT; Kadlec K; Schwarz S;
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1. Novel apramycin resistance gene apmA in bovine and porcine methicillin-resistant Staphylococcus aureus ST398 isolates. [J] . Fessler AT, Kadlec K, Schwarz S Antimicrobial agents and chemotherapy. . 2011,第1期

机译：牛和猪耐甲氧西林金黄色葡萄球菌ST398分离物中的新型阿霉素抗性基因apmA。
2. Novel erm(T)-carrying multiresistance plasmids from porcine and human isolates of methicillin-resistant Staphylococcus aureus ST398 that also harbor cadmium and copper resistance determinants [J] . Gómez-SanzE., KadlecK., Fe?lerA.T., Antimicrobial agents and chemotherapy. . 2013,第7期

机译：来自耐甲氧西林金黄色葡萄球菌ST398的猪和人分离株的新型携带erm（T）的多抗性质粒，还带有镉和铜抗性决定簇
3. Identification of a novel trimethoprim resistance gene, dfrK, in a methicillin-resistant Staphylococcus aureus ST398 strain and its physical linkage to the tetracycline resistance gene tet(L). [J] . Kadlec K, Schwarz S Antimicrobial agents and chemotherapy. . 2009,第2期

机译：在耐甲氧西林的金黄色葡萄球菌ST398菌株中鉴定出新的甲氧苄啶抗性基因dfrK，并与四环素抗性基因tet（L）物理连接。
4. Staphylococcus aureus Strains Isolated from Bovine Clinical Mastitis in New York State and Italy: Antibiotic-resistance Genes and Genotype Characteristics [C] . Annual Meeting of The National Mastitis Council . 2019

机译：从牛临床乳腺炎中分离的金黄色葡萄球菌菌株在纽约州和意大利：抗生素抗性基因和基因型特征
5. Influence of in vitro bacterial urokinase responsiveness on the in vivo pathogenesis of methicillin-sensitive Staphylococcus aureus and methicillin-resistant Staphylococcus aureus in mouse models. [D] . Yanke, Shawna Janine. 2000

机译：体外细菌尿激酶反应性对小鼠模型中甲氧西林敏感的金黄色葡萄球菌和耐甲氧西林的金黄色葡萄球菌的体内发病机理的影响。
6. Novel Apramycin Resistance Gene apmA in Bovine and Porcine Methicillin-Resistant Staphylococcus aureus ST398 Isolates [O] . Andrea T. Feßler, Kristina Kadlec, Stefan Schwarz 2011

机译：牛和猪耐甲氧西林金黄色葡萄球菌ST398分离株的新霉素抗性基因apmA
7. Novel Apramycin Resistance Gene apmA in Bovine and Porcine Methicillin-Resistant Staphylococcus aureus ST398 Isolates▿ [O] . Feßler, Andrea T., Kadlec, Kristina, Schwarz, Stefan 2010

机译：牛和猪耐甲氧西林金黄色葡萄球菌ST398分离株的新霉素抗性基因apmA

Novel apramycin resistance gene apmA in bovine and porcine methicillin-resistant Staphylococcus aureus ST398 isolates.

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