Therapeutic Efficacies of GW471552 and GW471558, Two New Azasordarin Derivatives, against Pneumocystosis in Two Immunosuppressed-Rat Models.

Jimenez E; Martinez A; Aliouat el M; Caballero J; Dei Cas E; Gargallo Viola D

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Therapeutic Efficacies of GW471552 and GW471558, Two New Azasordarin Derivatives, against Pneumocystosis in Two Immunosuppressed-Rat Models.

机译：在两种免疫抑制大鼠模型中，两种新的氮杂or子苷衍生物GW471552和GW471558的治疗功效均对肺囊肿病有效。

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Two new azasordarins, GW471552 and GW471558, were studied in vivo for treatment of Pneumocystis carinii pneumonia. In the Wistar rat spontaneous pneumonia model, both azasordarins significantly reduced the number of P. carinii cysts per gram of lung homogenate when administered at 1 mg/kg of body weight twice a day for 10 days. In a nude rat inoculation model, both compounds showed therapeutic efficacy at 0.25 mg/kg twice a day for 10 days.

机译：在体内研究了两种新的氮杂or仁，GW471552和GW471558，用于治疗卡氏肺孢子虫肺炎。在Wistar大鼠自发性肺炎模型中，当每天两次以1 mg / kg体重，连续10天给药时，两种氮杂均能显着降低每克肺匀浆中卡氏疟原虫囊肿的数量。在裸鼠接种模型中，两种化合物均以0.25 mg / kg的剂量每天两次治疗10天。

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来源
《Antimicrobial agents and chemotherapy.》 |2002年第8期|共3页
作者
Jimenez E; Martinez A; Aliouat el M; Caballero J; Dei Cas E; Gargallo Viola D;
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原文格式 PDF
正文语种 eng
中图分类治疗学;
关键词
Models; GW 471558; Pneumonia; Pneumocystis carinii; Therapeutic brand of coal tar; 肺炎; 卡氏肺囊虫;

机译：Models;GW 471558;Pneumonia;Pneumocystis carinii;Therapeutic brand of coal tar;肺炎;卡氏肺囊虫;

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1. Therapeutic Efficacies of GW471552 and GW471558, Two New Azasordarin Derivatives, against Pneumocystosis in Two Immunosuppressed-Rat Models. [J] . Jimenez E, Martinez A, Aliouat el M, Antimicrobial agents and chemotherapy. . 2002,第8期

机译：在两种免疫抑制大鼠模型中，两种新的氮杂or子苷衍生物GW471552和GW471558的治疗功效均对肺囊肿病有效。
2. Green tea epigallocatechin gallate enhances therapeutic efficacy of temozolomide in orthotopic mouse glioblastoma models. [J] . Chen TC, Wang W, Golden EB, Cancer letters . 2011,第2期

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机译：儿茶素及其衍生物预防阿尔茨海默氏病的治疗潜力。
6. Therapeutic Efficacies of GW471552 and GW471558 Two New Azasordarin Derivatives against Pneumocystosis in Two Immunosuppressed-Rat Models [O] . Elena Jimenez, Antonio Martínez, El Moukhtar Aliouat, 2002

机译：两种免疫抑制大鼠模型中两种新的氮杂za子衍生物GW471552和GW471558的治疗功效
7. Therapeutic Efficacies of GW471552 and GW471558, Two New Azasordarin Derivatives, against Pneumocystosis in Two Immunosuppressed-Rat Models [O] . Jimenez, Elena, Martínez, Antonio, Aliouat, El Moukhtar, 2002

机译：在两种免疫抑制大鼠模型中，两种新的氮杂or子衍生物GW471552和GW471558的治疗功效对肺囊肿

Therapeutic Efficacies of GW471552 and GW471558, Two New Azasordarin Derivatives, against Pneumocystosis in Two Immunosuppressed-Rat Models.

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