Topoisomerase Mutations Associated with In Vitro Selection of Resistance to Moxifloxacin in Streptococcus pneumoniae.

Houssaye S; Gutmann L; Varon E

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Topoisomerase Mutations Associated with In Vitro Selection of Resistance to Moxifloxacin in Streptococcus pneumoniae.

机译：与肺炎链球菌对莫西沙星耐药性的体外选择相关的拓扑异构酶突变。

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We analyzed the frequencies of selection, the order of acquisition, and the mutations selected on moxifloxacin in two wild-type pneumococcal strains, R6 and 5714. The first selection step showed either a single GyrA mutation or no mutation in any of the quinolone resistance-determining regions. Second-step mutants selected had either a second mutation in ParC or in ParE. Moxifloxacin could belong to these fluoroquinolones, which preferentially target GyrA though probably acting equally through both gyrase and topoisomerase IV.

机译：我们分析了两种野生型肺炎球菌R6和5714菌株的选择频率，获取顺序和在莫西沙星上选择的突变。第一步选择显示任何GyrA突变或任何喹诺酮耐药性无突变-确定区域。选择的第二步突变体在ParC或ParE中具有第二个突变。莫西沙星可能属于这些氟喹诺酮类药物，尽管可能同时通过回旋酶和拓扑异构酶IV起作用，但它们优先靶向GyrA。

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《Antimicrobial agents and chemotherapy.》 |2002年第8期|共4页
作者
Houssaye S; Gutmann L; Varon E;
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正文语种 eng
中图分类治疗学;
关键词
Mutation; Selection (Genetics); social resistance; Associated with; Streptococcus pneumoniae; 突变; 选择(遗传学); 链球菌; 肺炎;

机译：Mutation;Selection (Genetics);social resistance;Associated with;Streptococcus pneumoniae;突变;选择(遗传学);链球菌;肺炎;

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1. Topoisomerase Mutations Associated with In Vitro Selection of Resistance to Moxifloxacin in Streptococcus pneumoniae. [J] . Houssaye S, Gutmann L, Varon E Antimicrobial agents and chemotherapy. . 2002,第8期

机译：与肺炎链球菌对莫西沙星耐药性的体外选择相关的拓扑异构酶突变。
2. Single- and multi-step resistance selection study of gemifloxacin compared with trovafloxacin, ciprofloxacin, gatifloxacin and moxifloxacin in Streptococcus pneumoniae. [J] . Nagai K, Davies TA, Dewasse BE, The Journal of Antimicrobial Chemotherapy . 2001,第3期

机译：肺炎链球菌中吉非沙星与曲伐沙星，环丙沙星，加替沙星和莫西沙星的单步和多步抗药性选择研究。
3. Relative potential for selection of quinolone-resistance-determining-region mutations in Streptococcus pneumoniae by gemifloxacin, gatifloxacin and moxifloxacin. [J] . De Azavedo JC, Duncan CL, Kilburn L, Journal of chemotherapy . 2006,第4期

机译：用吉非沙星，加替沙星和莫西沙星在肺炎链球菌中选择喹诺酮耐药性决定区域突变的相对潜力。
4. STRUCTURAL AND MECHANISTIC BASIS FOR THE O-ACETYLATION OF PEPTIDOGLYCAN BY THE VIRULENCE FACTORS PatB OF Neisseria gonorrhoeae AND OatA FROM BOTH Staphylococcus aureus AND Streptococcus pneumoniae. [C] . Anthony J. Clarke, David Sychantha, Ashley Brott International Carbohydrate Symposium . 2018

机译：肽聚糖的结构和机械基础，肽因子毒力因子刺痛的因子和来自金黄色葡萄球菌的葡萄球菌和肺炎链球菌肺炎链球菌的毒性因子。
5. Efflux-mediated fluoroquinolone resistance and in vitro transformation studies in Streptococcus pneumoniae. [D] . Campbell, Sarah J. 2005

机译：肺炎链球菌外排介导的氟喹诺酮耐药性和体外转化研究。
6. Topoisomerase Mutations Associated with In Vitro Selection of Resistance to Moxifloxacin in Streptococcus pneumoniae [O] . Serge Houssaye, Laurent Gutmann, Emmanuelle Varon 2002

机译：拓扑异构酶突变与肺炎链球菌对莫西沙星耐药性的体外选择相关
7. Topoisomerase Mutations Associated with In Vitro Selection of Resistance to Moxifloxacin in Streptococcus pneumoniae [O] . Houssaye, Serge, Gutmann, Laurent, Varon, Emmanuelle 2002

机译：拓扑异构酶突变与肺炎链球菌对莫西沙星耐药性的体外选择相关

Topoisomerase Mutations Associated with In Vitro Selection of Resistance to Moxifloxacin in Streptococcus pneumoniae.

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