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首页> 外文期刊>Antimicrobial agents and chemotherapy. >Comparative Stability Studies of Antipseudomonal beta-Lactams for Potential Administration through Portable Elastomeric Pumps (Home Therapy for Cystic Fibrosis Patients) and Motor-Operated Syringes (Intensive Care Units).
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Comparative Stability Studies of Antipseudomonal beta-Lactams for Potential Administration through Portable Elastomeric Pumps (Home Therapy for Cystic Fibrosis Patients) and Motor-Operated Syringes (Intensive Care Units).

机译：通过便携式弹性体泵（囊性纤维化患者的家庭疗法）和电动注射器（重症监护病房）潜在给药的抗假性β-内酰胺的比较稳定性研究。

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The stability of antipseudomonal beta-lactams in concentrated solutions was examined in view of their potential administration by continuous infusion with external pumps (for intensive care patients) or with portable pumps carried under clothing (for cystic fibrosis patients). Aztreonam (100 g/liter), piperacillin (128 g/liter, with tazobactam), and azlocillin (128 g/liter) remained 90% stable for up to more than 24 h at 37 degrees C (mezlocillin [128 g/liter] was stable at 25 degrees C but not at 37 degrees C). Ceftazidime (120 g/liter), cefpirome (32 g/liter), and cefepime (50 g/liter) remained 90% stable for up to 24, 23.7, and 20.5 h at 25 degrees C but only for 8, 7.25, and 13 h at 37 degrees C, respectively. The control of temperature therefore appears to be critical for all three cephalosporins that cannot be recommended for use in portable pumps carried under clothes for prolonged periods for reasons of stability. Cefpirome and cefepime solutions developed an important color change (from light yellow to dark red) upon exposure when stored at 30 degrees C or higher. Degradation of ceftazidime was accompanied by the liberation of pyridine which, at 37 degrees C, was in excess of what is allowed by the U.S. Pharmacopeia, i.e., 1.1 mg/liter, after 8 and 12 h for drug concentrations of 12 and 8.3%, respectively. Imipenem and meropenem are too unstable (10% degradation at 25 degrees C after 3.5 and 5.15 h, respectively) to be recommended for use by continuous infusion. Faropenem, examined in comparison with imipenem and meropenem, proved as stable as aztreonam or piperacillin.
机译：考虑到抗假性β-内酰胺类药物在浓缩溶液中的稳定性，考虑到它们可能通过连续输注外部泵（对于重症监护患者）或在衣服下携带的便携式泵（对于囊性纤维化患者）进行潜在给药。 Aztreonam（100克/升），哌拉西林（128克/升，含他唑巴坦）和阿洛西林（128克/升）在37摄氏度（美洛西林[128克/升]）下可保持90％的稳定性达24小时以上。在25摄氏度时稳定，但在37摄氏度时不稳定）。头孢他啶（120克/升），头孢吡嗪（32克/升）和头孢吡肟（50克/升）在25°C下可保持24％，23.7和20.5小时的90％稳定性，但仅在8、7.25和在37摄氏度下分别保持13小时。因此，对于所有三种头孢菌素而言，温度的控制似乎都是至关重要的，出于稳定性的考虑，不建议将其长期用于衣服下携带的便携式泵中。当储存在30摄氏度或更高的温度下时，头孢吡肟和头孢吡肟溶液会发生重要的颜色变化（从浅黄色到深红色）。头孢他啶的降解伴随着吡啶的释放，在37摄氏度时，对于浓度为12％和8.3％的药物，在8和12小时后，吡啶的释放量超过了美国药典允许的水平，即1.1 mg / L。分别。亚胺培南和美罗培南太不稳定（分别在3.5和5.15 h后在25摄氏度下10％降解），因此不建议连续输注使用。与亚胺培南和美罗培南比较的法罗培南被证明与氨曲南或哌拉西林一样稳定。

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