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Longitudinal assessment of antipneumococcal susceptibility in the United States.

机译:在美国纵向评估抗肺炎球菌的敏感性。

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摘要

The prevalence of antimicrobial resistance among 4,940 U.S. pneumococcal isolates collected during 1999 was as follows: penicillin, 16.2%; amoxicillin-clavulanate, 12.2%; cefuroxime, 28.1%; ceftriaxone, 3.6%; trimethoprim-sulfamethoxazole, 30.3%; azithromycin, 21.4%; levofloxacin, 0.6%; and moxifloxacin, 0.1%. Compared to the previous 1997-1998 study (Jones et al., Antimicrob. Agents Chemother. 44:2645-2652, 2000), increases were noted for resistance to penicillin (3.7%; P < 0.001), amoxicillin-clavulanate (3.9%; P < 0.001), cefuroxime (5.7%; P < 0.001), azithromycin (2.4%; P = 0.014), trimethoprim-sulfamethoxazole (15.4%; P < 0.001), and levofloxacin (0.3%; P = 0.017). Resistance to ceftriaxone (0.1%; P = 0.809) and moxifloxacin (0.03%; P = 0.570) decreased. Concurrently, multidrug resistance increased (P < 0.001) from 6.3% to 11.3%.
机译:在1999年期间收集的4,940例美国肺炎球菌分离物中,抗菌素耐药性的发生率如下:青霉素为16.2%;阿莫西林-克拉维酸,12.2%;头孢呋辛28.1%;头孢曲松钠3.6%;甲氧苄啶-磺胺甲基恶唑,30.3%;阿奇霉素21.4%;左氧氟沙星0.6%;和莫西沙星,0.1%。与之前的1997-1998年研究(Jones等,Antimicrob.Agents Chemother。44:2645-2652,2000)相比,对青霉素(3.7%; P <0.001),阿莫西林-克拉维酸盐(3.9%)的耐药性有所增加; P <0.001),头孢呋辛(5.7%; P <0.001),阿奇霉素(2.4%; P = 0.014),甲氧苄啶-磺胺甲恶唑(15.4%; P <0.001)和左氧氟沙星(0.3%; P = 0.017)。对头孢曲松(0.1%; P = 0.809)和莫西沙星(0.03%; P = 0.570)的耐药性降低。同时,多药耐药性从6.3%增加到11.3%(P <0.001)。

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