Aspergillus is a ubiquitous, filamentous fungus found in soil and organic debris. Pulmonary aspergillosis generally is linked to the immunocompromised patient, whereas an aspergilloma or fungus ball is more likely to occur in a patient with a history of cavitary tuberculosis. In this clinical vignette, we report the case of a nonneutropenic, nontuberculosis patient with an aspergilloma. Historically, the standard of care in patients with an aspergilloma has been surgical resection; however, in this case we report the use of intracavitary amphotericin B infusion as an alternative.
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