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Growing pains of meta-analysis

机译:成长的烦恼的荟萃分析

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摘要

Meta-analysis is a statistical technique for pooling clinical trials of similar design. It achieves higher statistical power for detecting differences between treatments and obtaining more precise estimates of outcome. Meta-analysis quickly chalked up some notable successes after its introduction to medicine. Meta-analysis of several small studies suggested thrombolytic treatment would reduce mortality from acute myocardial infarction by 20%, a prediction confirmed by subsequent large randomised trials. The value of the meta-analysis in providing a quantitative overview of data from many studies soon became apparent. Optimists suggested that cumulative meta-analysis of small trials would identify effective treatments sooner, and there were even hints that meta-analysis might make large randomised trials unnecessary.
机译:元分析是一种统计方法池类似设计的临床试验。达到更高的统计检测治疗和获得之间的差异准确的估计结果。迅速取得了一些显著的成功其医学概论。几个小有研究表明溶栓从急性治疗可以降低死亡率心肌梗死20%,预测确认后续大型随机试验。在提供一个荟萃分析的价值定量数据从许多研究的概述很快变得明显。累积小试验的荟萃分析确定有效的治疗早,甚至暗示荟萃分析可能会使大型随机试验不必要的。

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