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首页> 外文期刊>BMJ: British medical journal >Insulin sensitivity and regular alcohol consumption: large, prospective, cross sectional population study (Bruneck study)
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Insulin sensitivity and regular alcohol consumption: large, prospective, cross sectional population study (Bruneck study)

机译：胰岛素敏感性和普通酒精消费:大型前瞻性,横截面人口研究(Bruneck研究)

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Objectives—To assess the relation between regular alcohol consumption and insulin sensitivity, and to estimate the importance of insulin in the association of alcohol with multiple vascular risk factors and cardiovascular disease. Design—Prospective and cross sectional study of a large randomly selected population sample. Setting—Part of the Bruneck study 1990-5 (Bolzano province, Italy). Subjects—820 healthy non-diabetic women and men aged 40-79 years. Main outcome measure—Concentrations of fasting and post-glucose insulin, cholesterol, apolipoproteins, triglycerides, Lp(a) lipoprotein, glucose, fibrinogen, and antithrombin Ⅲ; blood pressure; insulin resistance estimated by the homeostasis model assessment. Results—Fasting insulin concentrations in those who did not drink alcohol and subjects reporting low (1-50 g/day), moderate (51-99 g/day), and heavy ( ≥ 100 g/day) alcohol intake were 12.4, 10.0, 8.7, and 7.1 mU/1 (P < 0.001). Likewise, post-glucose insulin concentrations and estimates for insulin resistance assessed by the homeostasis model assessment decreased significantly with increasing amounts of regular alcohol consumption. These trends were independent of sex, body mass index, physical activity, cigarette smoking, medication, and diet (P < 0.001). Regular alcohol intake predicted multiple changes in vascular risk factors over a five year period including increased concentrations of high density lipoprotein cholesterol and apolipoprotein A Ⅰ; higher blood pressure; and decreased concentration of antithrombin Ⅲ. These associations were in part attributable to the decrease in insulin concentrations observed among alcohol consumers. Conclusions—Low to moderate amounts of alcohol, when taken on a regular basis, improve insulin sensitivity. Insulin is a potential intermediate component in the association between alcohol consumption and vascular risk factors (metabolic syndrome).
机译：目标定期评估之间的关系饮酒和胰岛素敏感性估计胰岛素的重要性协会与多个血管的酒精和心血管疾病危险因素。Design-Prospective和横断面研究人口大随机选择样本。Setting-Part Bruneck研究1990 - 5(博尔扎诺省、意大利)。非糖尿病40 - 79岁的男性和女性。衡量人的禁食和结果post-glucose胰岛素,胆固醇,载脂蛋白、甘油三酯、Lp (a)脂蛋白、葡萄糖、纤维蛋白原和抗凝血酶Ⅲ;电阻估计的内稳态模型评估。集中在那些不喝酒和主题报告(1-50 g /天)低,温和(51 - 99克/天)和重型酒精(≥100克/天)摄入量分别为12.4,10.0,8.7,和7.1亩/ 1 (P <0.001)。对胰岛素浓度和估计电阻内稳态模型评估评估显著降低,越来越多的普通酒精消费。性别、体重指数、体育活动,吸烟、药物治疗和饮食(P <0.001)。在五年的血管危险因素的变化期间包括增加的浓度高密度脂蛋白胆固醇和载脂蛋白Ⅰ;抗凝血酶的浓度减少Ⅲ。关联部分归因于减少胰岛素浓度观察中酒精的消费者。大量的酒精,当常规基础上,提高胰岛素敏感性。潜在的中间组件饮酒和之间的联系血管危险因素(代谢综合征)。

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