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首页> 外文期刊>Current medicinal chemistry-Anti-inflammatory & anti-allergy agents.Anti-inflammatory & anti-allergy agents >IRAKs: Key Regulatory Kinases of Innate Immunity
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IRAKs: Key Regulatory Kinases of Innate Immunity

机译：伊拉克共和国:先天免疫的关键调控激酶

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摘要

Toll-like receptors (TLRs), interleukin 1 receptor (IL-1R), IL-18 receptor (IL-18R) and plant R are vital to the induction of acute inflammation as well as various adaptive immune responses upon invasion of microorganisms. These receptors share a common cytoplasmic domain called the T1R (TLR/IL-lR/plant R) domain and the signaling cascade involving the TIR domain is conserved from invertebrate to vertebrate.The engagement of TIR domain containing receptors initiates their signaling through several intermediate proteins including serine-threonine kinase IL-1 receptor associated kinases (IRAKs) The IRAK family has four members and the newest member, IRAK-4, is indispensable to the TIR-mediated signaling pathway. The improper regulation of TIR receptor signaling leads to the development of such severe inflammatory diseases as sepsis, asthma, rheumatoid arthritis and even cancer. Therefore, it is very important to determine precisely the implications of TIR signaling in those inflammatory diseases for appropriate medical treatment and drug development. As IRAK-4 is the critical molecule for TIR-mediated signaling, it is a promising therapeutic target for many inflammatory diseases, In this review, we discuss the functions of the IRAK family members with focus on IRAK-4, to seek the possibility of yielding new therapeutic strategies.
机译：toll样受体(通常)、白介素1受体(IL-1R),地震-受体(IL-18R)和植物R对急性炎症的感应至关重要以及各种适应性免疫反应微生物的入侵。一个常见的胞质域称为T1R(TLR / IL-lR /植物R)域和信号级联涉及TIR域是守恒的从无脊椎动物到脊椎动物。包含受体发起行动领域信号通过一些中间的蛋白质包括serine-threonine激酶il - 1受体相关激酶(伊拉克共和国)伊拉克的家庭四个成员和新成员,IRAK-4,TIR-mediated信号不可或缺的途径。信号会导致如此严重的发展炎性疾病如脓毒症、哮喘、类风湿性关节炎,甚至癌症。是非常重要的决定的热红外信号的影响适当的医疗的炎性疾病治疗和药物开发。关键分子TIR-mediated信号是一种很有前途的治疗目标对于很多吗炎症性疾病,在本文中,我们讨论伊拉克的家庭成员的功能关注IRAK-4,寻求的可能性提供新的治疗策略。

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