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首页> 外文期刊>Current medicinal chemistry-Anti-inflammatory & anti-allergy agents.Anti-inflammatory & anti-allergy agents >Danger-Detector NKG2D: Immunosurveillance of Induced Self and Modulation by Cytokines and Soluble Ligands
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Danger-Detector NKG2D: Immunosurveillance of Induced Self and Modulation by Cytokines and Soluble Ligands

机译：危险探测仪NKG2D:免疫监视的诱导细胞因子和自我和调制可溶性配体

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摘要

The novel "induced self recognition mode mediated by the immunoreceptor NKG2D allows NK cells to eliminate dangerous and dysfunctional cells. Long-puzzling, complex NK cell reactivity patterns can now be explained -at least in part - by the combined action of the molecular players of the "missing self and "induced self hypotheses. Accordingly, MHC class I down-regulation in concert with an upregulated expression of self-ligands of activating NK receptors renders cells susceptible for NK cytotoxicity. The C-type lectin-like, activating NK receptor NKG2D detects a variety of inducibly expressed MHC class I-related molecules on stressed, infected, or malignant cells, and subsequently triggers effector functions of NK cells. Recent experiments also underline an important function of NKG2D on CD8 alphabeta T cells in tumor immunosurveillance and in the pathogenesis of autoimmune diseases. Here, we review the current knowledge on NKG2D and its ligands (NKG2DL) with regard to their structure, expression, and function, refer to recent data on the involvement of NKG2D in anti-viral immune defence, tumor surveillance, and autoimmune phenomena, and outline emerging evidence on the modulation of NKG2D by cytokines and soluble NKG2DL.
机译：小说《诱导介导的自我识别模式immunoreceptor NKG2D允许NK细胞消除危险和不正常的细胞。Long-puzzling、复杂的NK细胞活性模式现在可以解释——至少在某种程度上分子共同作用的球员“自我和缺失”的诱导自我假设。下调协同调节表达式的self-ligands激活NK为NK受体细胞呈现敏感细胞毒性。NK受体NKG2D检测多种诱导我跟分子表达MHC类强调,感染,或恶性细胞随后触发效应NK的函数细胞。重要NKG2D CD8 alphabeta T的函数细胞在肿瘤免疫监视自身免疫性疾病的发病机制。NKG2D及其审查当前的知识配体(NKG2DL)关于它们的结构,表达和功能,请参考最近的数据NKG2D在抗病毒免疫的参与国防、肿瘤监测和自身免疫性现象,和大纲新兴的证据调制NKG2D的细胞因子和可溶性NKG2DL .

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