Induction of Apoptotic Cell Death in Tumor Cells by S100A8/A9 Released from Inflammatory Cells Upon Cellular Activation

C. Kerkhoff; S. Ghavami

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Induction of Apoptotic Cell Death in Tumor Cells by S100A8/A9 Released from Inflammatory Cells Upon Cellular Activation

机译：诱导肿瘤细胞的凋亡细胞死亡S100A8 / A9释放炎性细胞在细胞活化

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摘要

Polymorphonuclear neutrophils (PMNs) have received less attention than other leukocyte subsets as potential mediators of antitumor effects, However, there is a growing body of evidence that PMNs are potential mediators of anti-tumor effects and play an important role in the antitumor response A protein complex S100A8/A9, formed by the two low molecular weight calcium-binding proteins S100A8 and S100A9, is released from activated PMNs and has apopto-sis/cytotoxicity-inducing activity against tumor cell lines, In this review, we focus on the molecular mechanisms by which S100A8/A9 induces apoptosis Recent studies point to a yet undefined mechanism, probably relaying on cell surface receptor(s), by which S100A8/A9 induces apoptosis in carcinoma cell lines, in addition to zinc exclusion from target cells. Although a number of putative receptors have been identified, the cell-membrane bindings site(s) involved in the apopto-sis-inducing activity of S100A8/A9 remain unknown. The identification of the binding site(s) together with the elucidation of the underlying molecular mechanisms will give new insights in how the adaptive immune system is involved in cancer regression.

机译：多形核中性粒细胞(中性粒细胞)已收到比其他白细胞子集的关注更少潜在的抗肿瘤效果,介质然而,有越来越多的证据中性粒细胞是抗肿瘤的潜在的介质影响和发挥着重要的作用抗肿瘤反应蛋白质复杂S100A8 / A9,由两个低分子量钙结合蛋白S100A8 S100A9,从激活中性粒细胞,并释放apopto-sis / cytotoxicity-inducing活动肿瘤细胞系,在本文中,我们关注的S100A8 / A9诱导的分子机制细胞凋亡最近的研究指出,一个未定义的机制,在细胞表面可能传送受体(s), S100A8 / A9凋亡在细胞癌行,除了锌被排除在目标细胞。假定的受体已确定,细胞膜绑定网站(s)参与apopto-sis-inducing S100A8 / A9活动依然存在未知的。网站的说明(s)在一起潜在的分子机制将给新的在适应性免疫系统的见解参与癌症的回归。

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来源
《Current medicinal chemistry-Anti-inflammatory & anti-allergy agents.Anti-inflammatory & anti-allergy agents》 |2005年第4期|383-391|共9页
作者
C. Kerkhoff; S. Ghavami;
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作者单位

Institute of Experimental Dermatology, Roentgenstr. 21, 48149 Muenster, Germany;

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原文格式 PDF
正文语种英语
中图分类药学;
关键词
tumor regression; Caspase Activation; Neoplastic CellAnoikisCell Deathzinc-binding proteinCalbindinsAntitumor ResponseCalgranulin B;

机译：肿瘤回归;半胱天冬酶激活肿瘤proteinCalbindinsAntitumor ResponseCalgranulin B;

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Induction of Apoptotic Cell Death in Tumor Cells by S100A8/A9 Released from Inflammatory Cells Upon Cellular Activation

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