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首页> 外文期刊>Current medicinal chemistry-Anti-inflammatory & anti-allergy agents.Anti-inflammatory & anti-allergy agents >Transcriptional Control of Metabolism, Inflammation and the Immune Response: The Role of PPARs
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Transcriptional Control of Metabolism, Inflammation and the Immune Response: The Role of PPARs

机译：转录控制新陈代谢,炎症和免疫反应:所扮演的角色PPARs

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Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors with key metabolic roles in adipose tissue, liver and skeletal muscle. They are also expressed at significant levels in polymorphonuclear cells, mono-cyte/macrophages, dendritic cells, T cells and B cells, suggesting that they may have a role in modulating the immune response. To date, evidence for such a role comes from numerous studies describing changes in gene expression within im-munoregulatory cells in response to pharmacological PPAR ligands, reports of beneficial effects of PPAR agonists in auto-immune disease in rodents, and accelerated auto-immune disease in genetically modified rodents with reduced PPAR expression. Coupled with the knowledge that the PPARs may act as "lipid sensors", these data have added to the growing scientific awareness of links between nutritional status and immune function.
机译：过氧物酶体proliferator-activated受体(PPARs)核激素受体与关键在脂肪组织的代谢作用,肝脏和骨骼肌。多形核细胞,显著水平mono-cyte /巨噬细胞、树突状细胞、T细胞和B细胞,这表明他们可能有一定的作用在调节免疫应答。证据来自无数的这样一个角色研究描述基因表达的变化在im-munoregulatory细胞响应药理PPAR配体的报道有益的PPAR激动剂在啮齿动物的自身免疫性疾病,加速在转基因的自身免疫性疾病啮齿动物与减少PPAR表达式。PPARs可以作为与知识“脂质传感器”,这些数据已经添加到越来越多的科学意识之间的联系营养状况和免疫功能。

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