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首页> 外文期刊>Current medicinal chemistry-Anti-inflammatory & anti-allergy agents.Anti-inflammatory & anti-allergy agents >Novel drugs for inflammatory lung diseases
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Novel drugs for inflammatory lung diseases

机译：炎症性肺部疾病的新药物

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摘要

Inflammation is a hallmark of several diseases of the lung including asthma and chronic obstructive pulmonary disease (COPD). There have been major advances in our understanding of the molecular processes underlying the development of inflammation in asthma and COPD.In this review we describe the development of novel anti-inflammatory strategies for the treatment of inflammatory lung disease such as chronic obstructive pulmonary disease, asthma, cystic fibrosis, acute respiratory distress syndrome, and pulmonary fibrosis.Basic concepts of inflammatory networks are described including overviews on involved cell types and mediators. The molecular mechanisms of current approaches of therapy for asthma and CODP such as corticosteroids, cromones, leukotriene inhibitors, antihistamines, and immunosuppressants are reviewed.The focus of the article is on novel approaches to treat inflammation in the airways. A general overview is given and includes new developments of steroids, receptor- and mediator-directed approaches, protease inhibitors, T cell modulators, inhibitors of cell signaling, and genetic therapy. Several examples of new therapies are outlined in more detail such as application of anti-IgE agents, CpG oligonucleotides, and therapies acting on transcription.
机译：炎症是几种疾病的一个特点包括哮喘和慢性阻塞性肺肺疾病(COPD)。我们理解的进步分子潜在的发展过程炎症在哮喘和慢性阻塞性肺病。描述小说的发展抗炎的治疗策略如慢性炎症性肺疾病阻塞性肺病、哮喘、囊性纤维化、急性呼吸窘迫综合征和肺纤维化。炎症网络包括描述概述细胞类型和介质。当前方法的分子机制治疗哮喘和CODP等糖皮质激素、cromones白三烯抑制剂、抗组胺药免疫抑制剂进行了综述。文章在新方法来治疗呼吸道的炎症反应。,包括新开发的类固醇受体,mediator-directed方法,蛋白酶抑制剂,T细胞调节器、细胞信号传导抑制剂基因疗法。治疗方法等详细介绍应用ige代理CpG寡核苷酸和治疗作用转录。

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