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首页> 外文期刊>Current medicinal chemistry-Anti-inflammatory & anti-allergy agents.Anti-inflammatory & anti-allergy agents >Selectins as targets in inflammatory diseases
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Selectins as targets in inflammatory diseases

机译：Selectins炎性疾病的目标

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摘要

Leukocyte recruitment is a multistep process and a key feature of tissue injury at sites of inflammation. Tissue accumulation of leukocytes is orchestrated by specific adhesion molecules regulating leukocyte-endothelial cell interactions, including rolling, firm adhesion and transmigration. Since the discovery and cloning of the selectin family of adhesion molecules (i e P-, E- and L-selectin) extensive investigative effort has been devoted to define the role of the selectins in the extravasation process of leukocytes in the microcirculation. Indeed, convincing evidence has documented that the selectins play a critical role in mediating leukocyte rolling along the endothelial cell lining. This review focuses on the mechanisms of leukocyte recruitment, especially leukocyte rolling, and the function and expression of the selectin family of adhesion molecules. Moreover, the therapeutic potential in targeting the selectins in selected inflammatory diseases, such as ischemia/reperfusion injury, artherosclerosis and endotoxemic liver injury will be described.
机译：白细胞招募是一个多步骤的过程,网站的组织损伤的关键特性炎症。是由特定的粘附分子策划调节leukocyte-endothelial细胞交互,包括滚动、粘附和轮回。克隆selectin家族的附着力分子(i e P - e -和L-selectin)广泛调查工作一直致力于定义的selectins外渗的作用微循环中白细胞的过程。事实上,令人信服的证据已经证明,在调停selectins发挥至关重要的作用沿着内皮细胞白细胞滚动内衬。白细胞招募,尤其是白细胞滚,功能和表达selectin粘附分子的家庭。针对的治疗潜力selectins在选定的炎性疾病,这样的artherosclerosis缺血/再灌注损伤将描述和endotoxemic肝损伤。

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