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首页> 外文期刊>Journal of cellular physiology. >Thyroid stimulating hormone aggravates diabetic retinopathy through the mitochondrial apoptotic pathway
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Thyroid stimulating hormone aggravates diabetic retinopathy through the mitochondrial apoptotic pathway

机译：促甲状腺激素加重糖尿病通过线粒体凋亡视网膜病变通路

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摘要

Diabetic retinopathy (DR) is a common complication of diabetes mellitus. High glucose-induced mitochondrial apoptosis is involved in the loss of retinal pericytes (PCs), which is considered to be a predominant pathologic change of diabetic retinopathy (DR). A high thyroid stimulating hormone (TSH) serum level is associated with an increased prevalence of DR in diabetic patients. Here, we investigated whether TSH regulated glucose-induced PCs loss through TSH-receptor (TSHR)-dependent mitochondrial apoptosis. First, the serum TSH level was found to be an independent risk factor for DR in Type 2 diabetic study participants (odds ratio = 2.294; 95% confidence interval: 1.925-2.733; p ≤ 0.001). Second, human PCs were treated with different concentrations of glucose, with or without bovine TSH (b-TSH). Glucose induced mitochondrial apoptosis through various mechanisms, including through regulating the expression of apoptosis-related proteins and inducing mitochondrial dysfunction, which could be deteriorated by costimulation of glucose and b-TSH. Additionally, we detected functional TSHR in PCs; blocking TSHR significantly restricted TSH-induced apoptosis. Thus, the presence of functional TSHR in human retinal PCs may facilitate the effect of high TSH on high glucose-induced PCs loss through TSHR-dependent mitochondrial apoptosis.
机译：糖尿病性视网膜病变(DR)是一种常见的并发症糖尿病。线粒体凋亡参与了损失视网膜的周(pc),这被认为是是糖尿病的主要病理改变性视网膜病变(DR)。血清激素(TSH)水平与一个关联博士在糖尿病患者的发病率增加。在这里,我们调查是否TSH监管通过TSH-receptor glucose-induced电脑损失(TSHR)端依赖线粒体凋亡。被发现是一个血清TSH水平2型糖尿病博士的独立危险因素研究参与者(优势比= 2.294;置信区间:1.925 - -2.733;第二,人类的电脑处理不同葡萄糖的浓度,或没有牛TSH (b-TSH)。通过各种机制、细胞凋亡等通过规范的表达apoptosis-related蛋白质和诱导线粒体功能障碍,这可能是葡萄糖和聚集有关的恶化b-TSH。在个人电脑;TSH-induced细胞凋亡。人类视网膜功能TSHR pc促进高TSH对高的效果通过TSHR-dependent glucose-induced电脑损失线粒体凋亡。

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