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The implications of the purinergic signaling throughout pregnancy

机译：purinergic信号的含义在怀孕

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摘要

Purinergic signaling is a necessary mechanism to trigger or even amplify cell communication. Its ligands, notably adenosine triphosphate (ATP) and adenosine, modulate specific membrane-bound receptors in virtually all human cells. Regardless of the stage of the pregnancy, cellular communication between maternal, placental, and fetal cells is the paramount mechanism to sustain its optimal status. In this review, we describe the crucial role of purinergic signaling on the regulation of the maternal-fetal trophic exchanges, immune control, and endocrine exchanges throughout pregnancy. The nature of the modulation of both ATP and adenosine on the embryo-maternal interface, going through placental invasion until birth delivery depends on the general maternal-fetal health state and consequently on the selective activation of their specific receptors. In addition, an increasing number of studies have been demonstrating the pivotal role of ATP and adenosine in modulating deleterious effects of suboptimal conditions of pregnancy. Here, we discuss the role of purinergic signaling on the balance that coordinates the embryo-maternal exchanges and a promising therapeutic venue in the context of pregnancy disorders.
机译：Purinergic信号是一个必要的机制触发甚至放大细胞通讯。配体,特别是三磷酸腺苷(ATP)和腺苷,调节特定的膜结合在几乎所有的人类细胞受体。不管怀孕的阶段,细胞之间的沟通孕产妇、胎盘,胎儿细胞是最重要的机制来维持其最佳状态。审查,我们描述的至关重要的作用purinergic信号的调节母胎营养交往,免疫控制,在怀孕期间和内分泌的交流。ATP和调制的性质腺苷embryo-maternal接口,走了通过胎盘侵入出生之前交货取决于一般的母胎健康状态,因此选择性激活他们的特定的受体。此外,越来越多的研究被证明ATP和的关键作用腺苷在调制的有害影响怀孕的理想条件。讨论purinergic信号上的作用平衡embryo-maternal坐标交流和一个有前途的治疗场所怀孕的疾病。

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