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首页> 外文期刊>Journal of cellular physiology. >Regulation of autophagy by protein methylation and acetylation in cancer
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Regulation of autophagy by protein methylation and acetylation in cancer

机译：自噬的调节蛋白质甲基化和乙酰化作用在癌症

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摘要

Autophagy is a highly conserved mechanism responsible for cellular homeostasis and integrity in a variety of physiological conditions. Materials targeted for degradation are directed to autophagosomes and autolysosomes, where they are broken down into their base components. Aberrant regulation of autophagy is significantly associated with various cancers and neurodegenerative diseases. Recently, accumulating evidence has revealed that the coordinated regulation of histone and non-histone protein modification is associated with autophagy. In this review, we highlight the recent progress that has been made in elucidating the molecular basis of protein methylation and acetylation associated with autophagy at the transcriptional and posttranslational levels. Furthermore, we discuss the importance of describing causality between protein methylation/acetylation and autophagy regulation as compelling therapeutic opportunities in cancer pathogenesis and progression.
机译：自噬是一个高度保守的机制细胞内稳态和负责在各种生理完整性条件。定向自噬体和自吞噬泡,他们分解为基础在哪里组件。明显与各种癌症和神经退行性疾病。越来越多的证据显示组蛋白和non-histone协调监管蛋白质与修改自噬。最近的进展,阐明了蛋白质甲基化的分子基础乙酰化作用与自噬的相关转录和转译后的水平。此外,我们讨论的重要性描述蛋白质之间的因果关系甲基化和乙酰化和自噬调节作为引人注目的治疗癌症的机会发病机理和发展。

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