...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of cellular physiology. >LINC00662: A new oncogenic lncRNA with great potential
【24h】

LINC00662: A new oncogenic lncRNA with great potential

机译：LINC00662:一个新的致癌lncRNA好了潜在的

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Abstract LINC00662 is located on chromosome 19q11 and is 2085?bp long. It is a long noncoding RNA (lncRNA) newly discovered. LINC00662 expression is upregulated in at least 14 tumors. In addition, the upregulation of LINC00662 expression is also closely related to the poor prognosis of cancer patients and resistance to radiotherapy and chemotherapy. LINC00662 can act as a ceRNA of at least 8 miRNAs. By regulating these miRNAs and their downstream genes, LINC00662 participates in the regulation of four signaling pathways, including the extracellular signal‐regulated kinase (ERK) signaling pathway, the Wnt/β‐catenin signaling pathway, the Hippo signaling pathway, and the SMD signaling pathway. In addition, the abnormal upregulation of LINC00662 can promote the stem‐like features of lung cancer cells. LINC00662 can reduce the promoter methylation level of s‐adenosylmethionine (SAM)‐dependent hepatocellular carcinoma?(HCC)‐promoting genes by regulating the MAT1A/SAM and AHCY/SAH axes, thereby promoting the activation of oncogenes. This article summarizes the molecular regulation mechanism of LINC00662 in cancer and the diagnostic and prognostic value of LINC00662 in cancer.
机译：文摘LINC00662位于染色体19的事情和是2085吗?(lncRNA)新发现。是至少14肿瘤调节。此外,LINC00662 upregulation表达式也密切相关癌症患者的预后和阻力放疗和化疗。作为一个龙头、至少8 microrna。这些microrna及其下游基因,LINC00662参与四的规定信号通路,包括细胞外信号调节激酶(ERK)信号通路,应承担的Wnt /β连环蛋白信号通路,应承担的河马信号通路,SMD信号通路。此外,upregulation异常LINC00662能促进茎类的特性肺癌细胞。启动子甲基化水平肝细胞癌吗? (HCC)促进基因的规范MAT1A /山姆和AHCY SAH轴,从而促进致癌基因的激活。本文总结了分子的监管在癌症和LINC00662机制LINC00662的诊断和预后价值癌症。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号