Structure, function and druggability of the African trypanosome flagellum

Julia Sáez Conde; Samuel Dean

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Structure, function and druggability of the African trypanosome flagellum

机译：的结构、功能和druggability非洲锥虫鞭毛

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Abstract African trypanosomes are early branching protists that cause human and animal diseases, termed trypanosomiases. They have been under intensive study for more than 100 years and have contributed significantly to our understanding of eukaryotic biology. The combination of conserved and parasite‐specific features mean that their flagellum has gained particular attention. Here, we discuss the different structural features of the flagellum and their role in transmission and virulence. We highlight the possibilities of targeting flagellar function to cure trypanosome infections and help in the fight to eliminate trypanosomiases.

机译：抽象的非洲锥虫早期分支原生生物,引起人类和动物疾病,称为trypanosomiases。深入研究了超过100年极大地推动了我们的理解真核生物。和寄生虫意味着他们的地理特性鞭毛得到了特别的关注。我们讨论的不同结构特点在传输和鞭毛及其作用毒性。针对h函数来治愈锥体虫感染和帮助消除的战斗中

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《Journal of cellular physiology.》 |2022年第6期|2654-2667|共14页
作者
Julia Sáez Conde; Samuel Dean;
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Division of Biomedical Sciences, Warwick Medical School,University of Warwick;

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Structure, function and druggability of the African trypanosome flagellum

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