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首页> 外文期刊>Journal of cellular physiology. >The cross‐talk between soluble “Find me” and “Keep out” signals as an initial step in regulating efferocytosis
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The cross‐talk between soluble “Find me” and “Keep out” signals as an initial step in regulating efferocytosis

机译：交叉检测可溶性“找我”和“保持之间的谈话“信号调节的初始步骤efferocytosis

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摘要

Abstract The rapid clearance of apoptotic cells (ACs), known as efferocytosis, prompts the inhibition of inflammatory responses and autoimmunity and maintains homeostatic cell turnover by controlling the release of intracellular contents. The fast clearance of ACs requires professional and nonprofessional phagocytic cells that can accurately and promptly recognize ACs and migrate towards them. Cells undergoing apoptosis alarm their presence by releasing special soluble chemotactic factors, such as lactoferrin, that act as “Find me,” “Keep out,”?or “Stay away” signals to recruit phagocytic cells, such as macrophages or prevent granulocyte migration. Efferocytosis effectively serves to prevent damage‐associated molecular pattern release and secondary necrosis and inhibit inflammation/autoimmunity at the very first step. Since less attention has been given to the cross‐talk and balance of “Find me” and “Keep out” signals released from ACs in efferocytosis, we set out to investigate the current knowledge of the roles of “Find me” and “Keep out” signals in the efferocytosis process.
机译：摘要快速凋亡细胞的清除(ACs),称为efferocytosis,提示抑制炎症反应自身免疫和维护自我平衡的细胞通过控制释放的营业额细胞内的内容。需要专业和非专业吞噬细胞,可以准确、迅速对他们识别ACs和迁移。进行细胞凋亡报警他们的存在释放特别可溶性趋化因子,如乳铁蛋白作为“找到我,”“保持”?吞噬细胞,如巨噬细胞或预防粒细胞迁移。为防止损伤相关的分子释放和继发性坏死和模式抑制炎症和自身免疫的的第一步。走上十字架的谈话和“找我”和平衡“保持”信号释放ACsefferocytosis,我们着手调查当前的知识“找我”的角色“保持”efferocytosis过程中的信号。

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  • 来源
    《Journal of cellular physiology.》 |2022年第8期|3113-3126|共14页
  • 作者

    Amir Tajbakhsh; Fatemeh Yousefi; Seyedeh M. AbediMehdi RezaeeAmir SavardashtakiYong TengAmirhossein Sahebkar;

  • 作者单位

    Pharmaceutical Sciences Research Center,Shiraz University of Medical Sciences;

    Department of Biological Sciences, Faculty of Genetics,Tarbiat Modares University;

    Student Research Committee,Shiraz University of Medical SciencesDepartment of Medical Biotechnology, School of Advanced Technologies,Shahrekord University ofInfertility Research Center,Shiraz University of Medical SciencesDepartment of Hematology and Medical Oncology, Winship Cancer Institute,Emory University School ofBiotechnology Research Center, Pharmaceutical Technology Institute,Mashhad University of Medical;

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