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首页> 外文期刊>Journal of cellular physiology. >Rapid responses of adipocytes to iron overload increase serum TG level by decreasing adiponectin
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Rapid responses of adipocytes to iron overload increase serum TG level by decreasing adiponectin

机译：脂肪细胞铁过载的快速反应脂联素通过减少增加血清TG水平

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摘要

Iron overload is tightly connected with metabolic disorders. Excess iron in the adipose and its roles in dyslipidemia are of interest to be identified. In acute iron overload mice receiving intraperitoneal injection of 100 mg/kg/day dextran-iron for 5 days, the epididymis adipose showed a remarkable increase in iron. Serum tri-glyceride and low-density lipoprotein cholesterol (LDL-C) levels were increased and high-density lipoprotein cholesterol (HDL-C) level was decreased, while serum alkaline phosphatase, aspartate aminotransferase, glucose, and insulin were not affected. The serum-cytokine-microarray showed that adipocytokines, including adiponectin, leptin, and resistin were significantly decreased. Other serum cyto-kines, including pro-insulin cytokines, inflammatory cytokines, chemokines, and growth factors were not changed, except that ghrelin and chemokine RANTES were increased. Iron overload decreased expressions of adiponectin and leptin both in vivo and in vitro. Intraperitoneal injection of recombinant leptin at 1 μg/g in acute iron overload mice had no significant effects on serum levels of TC, TG, HDL-C, and LDL-C, while intraperitoneal injection of recombinant adiponectin at 3 μg/g partially restored serum TG level through improving activities of lipoprotein lipase and hepatic lipase, but abnormal serum LDL-C and HDL-C were not redressed, suggesting other mechanisms also existed. In conclusion, the adipose responds to iron overload at an early stage to interfere with lipid metabolism by secreting adipocytokines, which may further affect glucose metabolism, inflammation, and other iron overload-induced effects on the body.
机译：铁过载与代谢紧密相连的障碍。角色在血脂异常感兴趣的识别。腹腔内注射100毫克/公斤/天dextran-iron 5天,附睾脂肪铁有显著提高。tri-glyceride和低密度脂蛋白胆固醇(低密度脂蛋白)水平增加,高密度脂蛋白胆固醇(hdl - c)水平下降,而血清碱性磷酸酶、天冬氨酸转氨酶、葡萄糖、和胰岛素不受影响。serum-cytokine-microarray显示adipocytokines,包括脂联素,瘦素,和抵抗素显著降低。血清cyto-kines,包括pro-insulin细胞因子、炎性细胞因子,趋化因子,和生长因子并没有改变,只是胃促生长素和趋化因子咆哮都增加了。过载降低脂联素的表达瘦素在体内和体外。注射重组瘦素在1μg / g急性铁超载小鼠没有明显影响血清TC、TG、hdl - c,和低密度,而腹腔内注射重组脂联素在3μg / g部分通过改善恢复血清TG水平脂蛋白脂酶和肝的活动脂肪酶,但异常血清低密度脂蛋白胆固醇和高密度脂蛋白胆固醇也没有得到纠正,这表明其他机制存在。铁过载在早期干涉脂质代谢分泌adipocytokines,这可能进一步影响葡萄糖代谢,炎症和其他铁overload-induced对身体的影响。

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