• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文OA文献 >Yusho patients show increased serum IL-17, IL-23, IL-1β, and TNFα levels more than 40 years after accidental polychlorinated biphenyl poisoning
【2h】

Yusho patients show increased serum IL-17, IL-23, IL-1β, and TNFα levels more than 40 years after accidental polychlorinated biphenyl poisoning

机译：Yusho patients show increased serum IL-17, IL-23, IL-1β, and TNFα levels more than 40 years after accidental polychlorinated biphenyl poisoning

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The Yusho poisoning incident, caused by rice oil contaminated with polychlorinated biphenyls (PCBs), polychlorinated quarterphenyls (PCQs), and polychlorinated dibenzofurans (PCDFs) generated by heat-denatured PCBs, occurred in 1968 in western Japan. Although severe symptoms are rarely observed today, the levels of PCBs and PCDFs in the sera of Yusho patients remain high. The aryl hydrocarbon receptor (AhR), which also acts as a dioxin receptor, is a transcriptional regulator that mediates dioxin toxicity. Recent studies show that dioxin mediates its immune toxic effects via AhR and that AhR activation induces dysregulation of interleukin (IL)-17-producing T (TH17) cells. This study therefore hypothesized that Yusho patients would show dysregulated TH17 cell-mediated immune responses. To validate the hypothesis, levels of IL-17 and IL-22, each secreted by TH17 cells, along with IL-1β and IL-23 were measured in serum samples from 40 Yusho patients and 40 age-matched controls. Levels of tumor necrosis factor (TNF)-α potentially secreted by TH17 cell-stimulated neutrophils and macrophages were also measured. The results indicated that serum IL-17 levels, as well as those of IL-1β, IL-23, and TNFα, were significantly higher in Yusho patients than in controls. In contrast, serum IL-22 levels were significantly lower in the Yusho patients. These results suggest that Yusho patients have dysregulated TH17 cell-mediated immune responses that may be linked to inflammation.
机译：由稻油被热变性多氯联苯产生的多氯联苯，多氯联苯和多氯二苯并呋喃污染的大米油于1968年在日本西部发生。尽管今天很少观察到严重的症状，但尤肖病人血清中的PCBs和PCDFs含量仍然很高。芳烃受体（AhR）也可作为二恶英受体，是一种介导二恶英毒性的转录调节因子。最近的研究表明，二恶英可通过AhR介导其免疫毒性作用，而AhR激活会诱导产生白介素（IL）-17的T（TH17）细胞失调。因此，本研究假设Yusho患者将显示TH17细胞介导的免疫反应失调。为了验证该假设，在来自40名Yusho患者和40个年龄匹配的对照组的血清样本中测量了TH17细胞分泌的IL-17和IL-22的水平，以及IL-1β和IL-23。还测量了TH17细胞刺激的中性粒细胞和巨噬细胞可能分泌的肿瘤坏死因子（TNF）-α的水平。结果表明，Yusho患者的血清IL-17水平以及IL-1β，IL-23和TNFα水平显着高于对照组。相反，Yusho患者的血清IL-22水平显着降低。这些结果表明，Yusho患者的TH17细胞介导的免疫反应异常，可能与炎症有关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号