...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of applied toxicology >Increased levels of urinary nitrite and nitrotyrosine in Yusho victims 40 years after accidental poisoning with polychlorinated biphenyls in Nagasaki, Japan.
【24h】

Increased levels of urinary nitrite and nitrotyrosine in Yusho victims 40 years after accidental poisoning with polychlorinated biphenyls in Nagasaki, Japan.

机译：在日本长崎，多氯联苯意外中毒后40年，Yusho受害者的尿中亚硝酸盐和硝基酪氨酸水平增加。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Forty years have passed since the accidental poisoning with polychlorinated biphenyls (PCB) in Japan in 1968, named Yusho. High concentrations of PCB are still detected in the serum of the Yusho victims. PCB produces superoxide (O(2) (-)) in the metabolic process and we reported high concentrations of serum nitrite, a stable metabolite reflecting nitric oxide (NO), in the Yusho victims. NO reacts with O(2) (-) and immediately produces peroxynitrite (ONOO(-)). ONOO(-) causes nitration of tyrosine residues and produces nitrotyrosine (NT). Therefore, we measured urinary concentrations of nitrite and NT in the victims and age-matched controls. The mean urinary concentrations of nitrite and NT were significantly higher than in the controls. There was a positive correlation between urinary nitrite and NT in the Yusho victims. Furthermore, there was a positive correlation between the ratio of urinary NT to nitrite and serum PCB concentrations in the Yusho victims. It was considered that the emergence of some ailments could be presumed to have been caused by high levels of urinary nitrite and NT in the Yusho victims. Copyright (c) 2008 John Wiley & Sons, Ltd.
机译：自1968年在日本因多氯联苯（PCB）意外中毒以来，已经过去了40年。在Yusho受害者的血清中仍检测到高浓度的PCB。 PCB在代谢过程中产生超氧化物（O（2）（-）），我们报道了Yusho受害人中高浓度的血清亚硝酸盐（一种稳定的代谢产物，反映一氧化氮（NO））。 NO与O（2）（-）反应，立即生成过氧亚硝酸盐（ONOO（-））。 ONOO（-）引起酪氨酸残基的硝化并产生硝基酪氨酸（NT）。因此，我们测量了受害者和与年龄匹配的对照组中尿液中亚硝酸盐和NT的浓度。亚硝酸盐和NT的平均尿液浓度显着高于对照组。 Yusho受害者中的亚硝酸尿与NT呈正相关。此外，Yusho受害者的尿液NT与亚硝酸盐之比与血清PCB浓度之间存在正相关。据认为，某些疾病的出现可能是由尤肖受害者中亚硝酸盐和尿液含量高引起的。版权所有（c）2008 John Wiley＆Sons，Ltd.

著录项

相似文献

  • 外文文献
  • 中文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号