Lipid peroxidation is enhanced in Yusho victims 35 years after accidental poisoning with polychlorinated biphenyls in Nagasaki, Japan.

Shimizu K; Ogawa F; Thiele JJ; Bae S; Sato S

首页> 外文期刊>Journal of applied toxicology >Lipid peroxidation is enhanced in Yusho victims 35 years after accidental poisoning with polychlorinated biphenyls in Nagasaki, Japan.

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Lipid peroxidation is enhanced in Yusho victims 35 years after accidental poisoning with polychlorinated biphenyls in Nagasaki, Japan.

机译：在日本长崎，多氯联苯意外中毒后35年，Yusho受害者的脂质过氧化作用增强。

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Thirty-five years have passed since the accidental poisoning with polychlorinated biphenyls (PCB) in Japan and yet high concentrations of PCB are still detected in the serum of the victims. PCB produces superoxide and thus victims are considered to be in a persistent state of oxidative stress. Urinary concentrations of 8-isoprostane (8IP) in the victims and age-matched controls were measured to assess this hypothesis. The mean urinary concentration of 8IP was significantly higher than that in the controls. There was a positive correlation between urinary 8IP and serum concentrations of cholinesterase. It was considered that Yusho is an oxidative stress and 8IP is a useful tool for checking the oxidative condition in Yusho victims.

机译：自从日本多氯联苯（PCB）意外中毒以来已经过去了35年，但在受害者的血清中仍检测到高浓度的PCB。 PCB会产生超氧化物，因此受害者被认为处于持续的氧化应激状态。测量受害者和年龄匹配的对照组中尿中8-异前列腺素（8IP）的浓度以评估该假设。 8IP的平均尿液浓度显着高于对照组。尿液8IP与血清胆碱酯酶浓度呈正相关。人们认为Yusho是一种氧化应激，而8IP是检查Yusho受害者氧化状况的有用工具。

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来源
《Journal of applied toxicology》 |2007年第2期|共3页
作者
Shimizu K; Ogawa F; Thiele JJ; Bae S; Sato S;
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正文语种 eng
中图分类毒物学（毒理学）;
关键词
Polychlorinated Biphenyls; Poisoning aspects; Japan; Oxidative Stress; 多氯联苯化合物; 日本; 氧化性应激;

机译：Polychlorinated Biphenyls;Poisoning aspects;Japan;Oxidative Stress;多氯联苯化合物;日本;氧化性应激;

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1. Lipid peroxidation is enhanced in Yusho victims 35 years after accidental poisoning with polychlorinated biphenyls in Nagasaki, Japan. [J] . Shimizu K, Ogawa F, Thiele JJ, Journal of applied toxicology . 2007,第2期

机译：在日本长崎，多氯联苯意外中毒后35年，Yusho受害者的脂质过氧化作用增强。
2. Serum antioxidant levels in Yusho victims over 30 years after the accidental poisoning of polychlorinated biphenyls in Nagasaki, Japan. [J] . Shimizu K, Ogawa F, Watanabe M, Toxicology and Industrial Health . 2003,第2a6期

机译：在日本长崎，多氯联苯意外中毒后的30年间，汤庄受害者的血清抗氧化剂水平升高。
3. Yusho patients show increased serum IL-17, IL-23, IL-1 beta, and TNF alpha levels more than 40 years after accidental polychlorinated biphenyl poisoning [J] . Kuwatsuka Yutaka, Shimizu Kazuhiro, Akiyama Yuichiro, Journal of immunotoxicology. . 2014,第1a4期

机译：Yusho患者在多氯联苯中毒意外发生40多年后显示血清IL-17，IL-23，IL-1β和TNFα水平升高
4. Organochlorine Pesticides and Polychlorinated Biphenyls (PCBs) in Early Adulthood and Blood Lipids over a 23-Year Follow-Up [C] . Jose R. Suarez-Lopez, Chase G. Clemesha, Miquel Porta, Joint annual meeting of the International Society of Exposure Science and the International Society for Environmental Epidemiology . 2018

机译：在长达23年的随访中，成年早期和血脂中的有机氯农药和多氯联苯（PCB）
5. Effects of polychlorinated biphenyls on vascular endothelial cell dysfunction: Modification by dietary lipids. [D] . Slim, Rabih Mohamad. 2000

机译：多氯联苯对血管内皮细胞功能障碍的影响：饮食脂质的修饰。
6. Association of clinical findings in Yusho patients with serum concentrations of polychlorinated biphenyls polychlorinated quarterphenyls and 23478-pentachlorodibenzofuran more than 30 years after the poisoning event [O] . Yoshiyuki Kanagawa, Shinya Matsumoto, Soichi Koike, 2008

机译：中毒事件发生超过30年后与Yusho患者的临床发现与血清中多氯联苯多氯联苯和23478-五氯二苯并呋喃的浓度相关
7. Yusho patients show increased serum IL-17, IL-23, IL-1β, and TNFα levels more than 40 years after accidental polychlorinated biphenyl poisoning [O] . Kuwatsuka Yutaka, Shimizu Kazuhiro, Akiyama Yuichiro, 2014

机译：Yusho patients show increased serum IL-17, IL-23, IL-1β, and TNFα levels more than 40 years after accidental polychlorinated biphenyl poisoning
8. PCBs (Polychlorinated Biphenyls), PCDDs (Polychlorinated Dibenzo-P-Dioxins) and PCDFs (Polychlorinated Dibenzofurans): Prevention and Control of Accidental and Environmental Exposure [R] . 1987

机译：多氯联苯（多氯联苯），多氯二苯并二恶英（多氯二苯并二恶英）和多氯二苯并呋喃（多氯二苯并呋喃）：预防和控制意外和环境暴露

Lipid peroxidation is enhanced in Yusho victims 35 years after accidental poisoning with polychlorinated biphenyls in Nagasaki, Japan.

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