A link between protein acetylation and mitochondrial dynamics under energy metabolism: A comprehensive overview

Huihui Gu; Kun Yang; Qiong WuZhentong ShenXinjian LiChao Sun

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A link between protein acetylation and mitochondrial dynamics under energy metabolism: A comprehensive overview

机译：蛋白质乙酰化和之间的联系线粒体动力学能量代谢:下一个全面的概述

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Cells adjust mitochondrial morphologies to coordinate between the cellular demand for energy and the availability of resources. Mitochondrial morphology is regulated by the balance between two counteracting mitochondrial processes of fusion and fission. Fission and fusion are dynamic and reversible processes that depend on the coordination of a number of proteins and are primarily regulated by posttransla-tional modifications. In the mitochondria, more than 20% of proteins are acetylated in proteomic surveys, partly involved in the dynamic regulation of mitochondrial fusion and fission. This article focuses on the molecular mechanism of the mitochondrial dynamics of fusion and fission, and summarizes the related mechanisms and targets of mitochondrial protein acetylation to regulate the mitochondrial dynamics of fusion and fission in energy metabolism.

机译：细胞线粒体形态调整细胞对能源的需求之间的协调和资源的可用性。形态是由之间的平衡两个抵消线粒体的过程聚变和裂变。动态和依赖的可逆过程许多蛋白质和协调主要由posttransla-tional修改。的蛋白质乙酰化蛋白质组调查,部分参与的动态监管线粒体融合与分裂。关注的分子机制线粒体动力学聚变和裂变,总结了相关机制和目标线粒体蛋白质乙酰化调节线粒体动力学的聚变和裂变能量代谢。

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来源
《Journal of cellular physiology.》 |2021年第12期|7926-7937|共12页
作者
Huihui Gu; Kun Yang; Qiong WuZhentong ShenXinjian LiChao Sun;
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作者单位

Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of;

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原文格式 PDF
正文语种英语
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关键词
ACETYLATION; Energy Metabolism; Mitochondrial DynamicsFissionFUSIONreversible processFusion, biologicalMitochondria;

机译：乙酰化作用、能量代谢、线粒体DynamicsFissionFUSIONreversible processFusion,;

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A link between protein acetylation and mitochondrial dynamics under energy metabolism: A comprehensive overview

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