Enolase-phosphatase 1 acts as an oncogenic driver in glioma

Bo Wang; Xin Xu; Xi LiuDong WangHao ZhuangXin HeTong HanJian Hong

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Enolase-phosphatase 1 acts as an oncogenic driver in glioma

机译：Enolase-phosphatase 1作为致癌的司机在神经胶质瘤

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Enolase-phosphatase 1 (ENOPH1), a newly identified enzyme involved in L-methionine biosynthesis, is associated with anxiety and depression. In this study, ENOPH1 was found to play a crucial role in promoting the proliferation and migration of glioma cells. Among high-grade glioma patients, the overall survival of the group showing high ENOPH1 expression was shorter than that of the group showing low ENOPH1 expression. ENOPH1 knockdown inhibited glioma cell proliferation and migration. In parallel, ENOPH1 knockdown suppressed tumor growth capacity and prolonged survival in an orthotopic glioma model. Mechanistically, we found that ENOPH1 activates the PI3K/AKT/mTOR signaling pathway by regulating THEM4. In conclusion, ENOPH1 is an important mediator that promotes glioma cell proliferation and migration.

机译：Enolase-phosphatase 1 (ENOPH1),一个新发现酶参与L-methionine生物合成,与焦虑和抑郁有关。研究中,发现ENOPH1发挥至关重要的作用促进扩散和迁移神经胶质瘤细胞。群体的整体存活率高ENOPH1表达式是短的组显示低ENOPH1表达式。可拆卸的抑制胶质瘤细胞增殖迁移。抑制肿瘤的生长和长时间的能力生存在一个原位神经胶质瘤模型。从力学上看,我们发现ENOPH1激活mTOR / PI3K / AKT信号通路的调节THEM4。中介,促进神经胶质瘤细胞增殖和迁移。

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来源
《Journal of cellular physiology.》 |2021年第2期|1184-1194|共11页
作者
Bo Wang; Xin Xu; Xi LiuDong WangHao ZhuangXin HeTong HanJian Hong;
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作者单位

Department of Neurosurgery, Tianjin Huanhu Hospital, Tianjin Key Laboratory of Cerebral Vascular;

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正文语种英语
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关键词
Immigration; Glioma; Glioma cellsCell Proliferation;

机译：移民;神经胶质瘤;神经胶质瘤cellsCell增殖;

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Enolase-phosphatase 1 acts as an oncogenic driver in glioma

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