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首页> 外文期刊>Journal of cellular physiology. >Ten-m/Odz3 regulates migration and differentiation of chondrogenic ATDC5 cells via RhoA-mediated actin reorganization
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Ten-m/Odz3 regulates migration and differentiation of chondrogenic ATDC5 cells via RhoA-mediated actin reorganization

机译：Ten-m / Odz3调节迁移和分化通过RhoA-mediated的chondrogenic ATDC5细胞肌动蛋白重组

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摘要

Tenascin-like molecule major (Ten-m)/odd Oz (Odz), a type II transmembrane molecule, is well known to modulate neural development. We have reported that Ten-m/Odz3 is expressed in cartilaginous tissues and cells. Actin cytoskeleton and its regulator ras homolog gene family member A (RhoA) are closely associated with chondrogenesis. The present study aimed to evaluate the function and molecular mechanism of Ten-m/Odz3 during chondrogenesis, focusing on RhoA and the actin cytoskeleton. Ten-m/Odz3 was expressed in precartilaginous condensing mesench-yme in mouse limb buds. Ten-m/Odz3 knockdown in ATDC5 induced actin cytoskeleton reorganization and change of cell shape through modulation of RhoA activity and FGF2 expression. Ten-m/Odz3 knockdown suppressed ATDC5 migration and expression of genes associated with chondrogenesis, such as Sox9 and type II collagen, via RhoA. On the other hand, Ten-m/Odz3 knockdown inhibited proliferation of ATDC5 in a RhoA-independent manner. These findings suggest that Ten-m/Odz3 plays an important role in early chondrogenesis regulating RhoA-mediated actin reorganization.
机译：Tenascin-like分子主要(Ten-m) /奇怪Oz (Odz),II型跨膜分子,是众所周知的调节神经的发展。在软骨Ten-m / Odz3表示组织和细胞。监管机构ras同族体基因家族成员(RhoA)与软骨形成密切相关。本研究旨在评估函数和分子机制Ten-m / Odz3期间软骨形成,关注RhoA和肌动蛋白细胞骨架。precartilaginous冷凝mesench-yme鼠标肢芽。肌动蛋白细胞骨架重组和改变的细胞形状通过调制RhoA活动和FGF2表达式。抑制ATDC5迁移和表达的与软骨形成相关的基因,如通过RhoA Sox9和II型胶原蛋白。一方面,Ten-m / Odz3击倒抑制RhoA-independent ATDC5扩散的方式。早期软骨形成中发挥着重要作用调节RhoA-mediated肌动蛋白重组。

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