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首页> 外文期刊>Journal of cellular physiology. >Codon usage pattern and evolutionary forces of mitochondrial ND genes among orders of class Amphibia
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Codon usage pattern and evolutionary forces of mitochondrial ND genes among orders of class Amphibia

机译：密码子使用模式和进化的力量线粒体基因和订单之间的类两栖类

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摘要

In this study, we used a bioinformatics approach to analyze the nucleotide composition and pattern of synonymous codon usage in mitochondrial ND genes in three amphibian groups, that is, orders Anura, Caudata, and Gymnophiona to identify the commonality and the differences of codon usage as no research work was reported yet. The high value of the effective number of codons revealed that the codon usage bias (CUB) was low in mitochondrial ND genes among the orders. Nucleotide composition analysis suggested that for each gene, the compositional features differed among Anura, Caudata, and Gymnophiona and the GC content was lower than AT content. Furthermore, a highly significant difference (p < .05) for GC content was found in each gene among the orders. The heat map showed contrasting patterns of codon usage among different ND genes. The regression of GC12 on GC3 suggested a narrow range of GC3 distribution and some points were located in the diagonal, indicating both mutation pressure and natural selection might influence the CUB. Moreover, the slope of the regression line was less than 0.5 in all ND genes among orders, indicating natural selection might have played the dominant role whereas mutation pressure had played a minor role in shaping CUB of ND genes across orders.
机译：在这项研究中,我们使用一个生物信息学方法分析核苷酸组成和模式线粒体ND的同义密码子的使用基因在三个两栖动物组,订单无尾目动物、有尾目和蚓螈目来识别的密码子使用的共性和差异没有报道的研究工作。密码子的有效数字显示密码子使用偏见(宝宝)很低线粒体基因和订单。核苷酸成分分析建议每个基因的组成特性无尾目动物之间不同,有尾目、蚓螈目和GC含量低于内容。此外,一个高度显著性差异(p <. 05)被发现在每个基因GC内容的订单。在不同的密码子使用模式和基因。回归的GC12 GC3建议一个狭窄GC3分布范围和一些点位于对角线,表明这两个突变自然选择压力和可能的影响幼崽。线是所有ND基因在小于0.5命令,指示自然选择发挥了主导作用而变异压力在塑造宝宝扮演一个次要角色在订单和基因。

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