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首页> 外文期刊>Journal of cellular physiology. >Myokines mediate the cross talk between skeletal muscle and other organs
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Myokines mediate the cross talk between skeletal muscle and other organs

机译：Myokines调解骨骼之间的相声肌肉和其他器官

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摘要

Myokines are muscle-derived cytokines and chemokines that act extensively on organs and exert beneficial metabolic functions in the whole-body through specific signal networks. Myokines as mediators provide the conceptual basis for a whole new paradigm useful for understanding how skeletal muscle communicates with other organs. In this review, we summarize and discuss classes of myokines and their physiological functions in mediating the regulatory roles of skeletal muscle on other organs and the regulation of the whole-body energy metabolism. We review the mechanisms involved in the interaction between skeletal muscle and nonmuscle organs through myokines. Moreover, we clarify the connection between exercise, myokines and disease development, which may contribute to the understanding of a potential mechanism by which physical inactivity affects the process of metabolic diseases via myokines. Based on the current findings, myokines are important factors that mediate the effect of skeletal muscle on other organ functions and whole-body metabolism.
机译：Myokines肌源性细胞因子和趋化因子,在器官和广泛发挥有益的代谢功能全身通过特定的信号网络。Myokines作为调解人提供概念依据一个全新范式有用了解骨骼肌进行通信与其他器官。并讨论myokines类和他们的生理功能的调节骨骼肌的监管角色器官和全身的监管能量代谢。参与骨骼之间的交互肌肉和通过myokines nonmuscle器官。此外,我们澄清之间的联系锻炼,myokines和疾病发展可能导致的理解缺乏身体活动的潜在机制影响代谢疾病的过程中通过myokines。调解是重要因素的影响在其他器官功能和骨骼肌全身的新陈代谢。

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