Emerging role of CCN family proteins in fibrosis

CHAO SUN; HAN ZHANG; AND XINHUI LIU

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Emerging role of CCN family proteins in fibrosis

机译：新兴CCN家族蛋白在肝纤维化的作用

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Fibrosis is a common pathological change characterized by the excessive accumulation of fibrous connective tissue. Once uncontrolled, this pathological progress can lead to irreversible damage to the structure and function of organs, which is a serious threat to human health and life. Actually, the disability and death of patients caused by many chronic diseases have a closed relationship with fibrosis. The CCN protein family, including six members, is a small group of matrix proteins exhibiting structurally similar features. In the past 20 years, different biological functions of CCN proteins have been identified in various diseases. Of note, it has been recently shown that they are implicated in the key pathological process of fibrosis. In this review, we summarize the current status of knowledge regarding the role of CCN proteins involved in the pa-thogenesis of fibrosis diseases in detail. Furthermore, we highlight some of the underlying interaction mechanisms of CCN protein acting in fibrosis that helps to develop new drugs and determine appropriate clinical strategies for fibrotic diseases.

机译：纤维化是一种常见的病理变化的过度积累纤维结缔组织。这可能导致病理进展不可逆损伤的结构和功能的器官,这是一种严重威胁人类健康和生命。许多慢性疾病造成死亡的患者有一个封闭与肝纤维化的关系。蛋白质家族,包括六名成员,是一个小的群矩阵蛋白表现出结构类似的功能。CCN蛋白质的生物功能确定在各种疾病。最近表明,他们是参与纤维化的病理过程的关键。审查中,我们总结的当前状态知识对于CCN的蛋白质的作用参与pa-thogenesis纤维化详细的疾病。一些潜在的交互机制帮助CCN蛋白的纤维化开发新的药物和确定合适的纤维化疾病的临床策略。

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来源
《Journal of cellular physiology.》 |2021年第6期|4195-4206|共12页
作者
CHAO SUN; HAN ZHANG; AND XINHUI LIU;
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作者单位

Department of Spine Surgery, the Affiliated Jiangning Hospital with Nanjing Medical University;

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原文格式 PDF
正文语种英语
中图分类
关键词
CCN Intercellular Signaling Proteins; human health; Fibrosismatrix proteinsTransforming Growth Factor betaExtracellular MatrixMyofibroblastscurrent statusProtein FamilyFibrous connective tissue;

机译：CCN细胞间信号传导蛋白;人类健康;Fibrosismatrix proteinsTransforming增长因素betaExtracellularMatrixMyofibroblastscurrent statusProteinFamilyFibrous结缔组织;

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Emerging role of CCN family proteins in fibrosis

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