Gene coexpression analysis offers important modules and pathway of human lung adenocarcinomas

Zhongheng Wei; Tan Zhongqiu; Shuxiong LuFang ZhangWei XieYing Wang

首页> 外文期刊>Journal of cellular physiology. >Gene coexpression analysis offers important modules and pathway of human lung adenocarcinomas

【24h】

Gene coexpression analysis offers important modules and pathway of human lung adenocarcinomas

机译：基因coexpression分析提供了重要模块和人类肺腺癌的途径

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Lung adenocarcinomas injured greatly on the people worldwide. Although clinic experiments and gene profiling analyses had been well performed, to our knowledge, systemic coexpression analysis of human genes for this cancer is still limited to date. Here, using the published data GSE75037, we built the coexpression modules of genes by Weighted Gene Co-Expression Network Analysis (WGCNA), and investigated function and protein-protein interaction network of coexpression genes by Database for Annotation, visualization, and Integrated Discovery (DAVID) and String database, respectively. First, 11 coexpression modules were conducted for 5,000 genes in the 83 samples recently. Number of genes for each module ranged from 90 to 1,260, with the mean of 454. Second, interaction relationships of hub-genes between pairwise modules showed great differences, suggesting relatively high scale independence of the modules. Third, functional enrichment of the coexpression modules showed great differences. We found that genes in modules 8 significantly enriched in the biological process and/or pathways of cell adhesion, extracellular matrix (ECM)-receptor interaction, focal adhesion, and PI3K-Akt signaling pathway, and so forth. It was inferred as the key module underlying lung adenocarcinomas. Furthermore, PPI analysis revealed that the genes COL1A1, COL1A2, COL3A1, CTGF, and BGN owned the largest number of adjacency genes, unveiling that they may functioned importantly during the occurrence of lung adenocarcinomas. To summary, genes involved in cell adhesion, ECM-receptor interaction, focal adhesion, and PI3K-Akt signaling pathway play crucial roles in human lung adenocarcinomas.

机译：肺腺癌受伤很大程度上在全球范围内。分析分析被执行,我们所知,系统性coexpression分析人类基因癌症仍然是有限的日期。建立了coexpression模块的基因加权基因Co-Expression网络分析(WGCNA),功能和调查蛋白质相互作用网络coexpression基因数据库的注释,可视化、发现和集成(大卫)分别和字符串数据库。5000年coexpression模块进行最近的83个样本的基因。为每个模块范围从90年到1260年,与454的意思是。hub-genes成对模块之间表现出极大的差异,表明相对较高的规模独立的模块。浓缩的coexpression模块显示大的差异。8显著富集在生物过程和/或细胞粘附的通路,细胞外基质(ECM)受体相互作用,粘着斑和PI3K-Akt信号通路,等等。潜在的肺腺癌。分析显示,基因COL1A1 COL1A2,COL3A1、CTGF和BGN拥有最多的他们可能邻接基因,揭幕重要的是在发生肺腺癌。在细胞粘附,ECM-receptor交互,焦附着力,PI3K-Akt信号通路至关重要的角色在人类肺腺癌。

著录项

来源
《Journal of cellular physiology.》 |2020年第1期|454-464|共11页
作者
Zhongheng Wei; Tan Zhongqiu; Shuxiong LuFang ZhangWei XieYing Wang;
展开▼
作者单位

Department of Oncology, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise;

展开▼
收录信息
原文格式 PDF
正文语种英语
中图分类
关键词
Protein-Protein Interaction; Adenocarcinoma; Cell AdhesionLungPathwayPi3K/Akt signalingAdenocarcinoma of lung;

机译：蛋白质交互作用;腺癌;细胞AdhesionLungPathwayPi3K /幕signalingAdenocarcinoma肺癌;

相似文献

外文文献
中文文献

1. Human sodium/iodide symporter gene induced iodine uptake in human lung adenocarcinoma via baculovirus [J] . GUO Rui, ZHANG Yifan, LIANG Sheng, 核技术：英文版 . 2010,第002期
2. Human sodium/iodide symporter gene induced iodine uptake in human lung adenocarcinoma via baculovirus [J] . GUO Rui, ZHANG Yifan, LIANG Sheng, 核技术（英文版） . 2010,第002期
3. Effects of Inotodiol Extracts from Inonotus Obliquus on Proliferation Cycle and Apoptotic Gene of Human Lung Adenocarcinoma Cell Line A549 [J] . 钟秀宏, 王立波, 孙东植中国结合医学杂志：英文版 . 2011,第002期
4. Bayes Theorem; Confidence Intervals; France; Humans; Incidence; Income; Lung Neoplasms; Male; Middle Aged; Regression Analysis; Risk; Sex Factors; Socioeconomic Factors; Urban Population;*成年人; 年龄因素; 老年人; 老年人, 80以上; 贝叶斯定理; 置信区间; 法国; 发病率; 收入; 肺肿瘤; 回归分析; 危险; 性别因素; 社会经济因素; 市区人口 [J] . Quality of life research: An international journal of quality of life aspects of treatment, care and rehabilitation . 2009,第8期

机译：Bayes Theorem; Confidence Intervals; France; Humans; Incidence; Income; Lung Neoplasms; Male; Middle Aged; Regression Analysis; Risk; Sex Factors; Socioeconomic Factors; Urban Population;*成年人; 年龄因素; 老年人; 老年人, 80以上; 贝叶斯定理; 置信区间; 法国; 发病率; 收入; 肺肿瘤; 回归分析; 危险; 性别因素; 社会经济因素; 市区人口
5. Adu; Aged;; Aged, 80 and over;; Antineoplastic Agents;; Carcinoma, Non-Small-Cell Lung;; Cisplatin;; Cohort Studies;; Deoxycytidine;; Female;; Humans;; Lung Neoplasms;; Male;; Middle Aged;; Mitomycin;; Neoadjuvant Therapy;; Neoplasm Staging;; Pneumonectomy;; Retrospective Studies;; Treatment Outcome;; Vinblastine;; *成年人;; 老年人;; 老年人, 80以上;; 抗肿瘤药;; 癌, 非小细胞肺;; 顺铂;; 队列研究;; 脱氧胞苷;; 肺肿瘤;; 肿瘤辅助疗法;; 肿瘤分期;; 肺切除术;; 回顾性研究;; 治疗结果;; 长春碱 [J] . Clinical cancer research: an official journal of the American Association for Cancer Research . 2009,第18期

机译：Adu; Aged;; Aged, 80 and over;; Antineoplastic Agents;; Carcinoma, Non-Small-Cell Lung;; Cisplatin;; Cohort Studies;; Deoxycytidine;; Female;; Humans;; Lung Neoplasms;; Male;; Middle Aged;; Mitomycin;; Neoadjuvant Therapy;; Neoplasm Staging;; Pneumonectomy;; Retrospective Studies;; Treatment Outcome;; Vinblastine;; *成年人;; 老年人;; 老年人, 80以上;; 抗肿瘤药;; 癌, 非小细胞肺;; 顺铂;; 队列研究;; 脱氧胞苷;; 肺肿瘤;; 肿瘤辅助疗法;; 肿瘤分期;; 肺切除术;; 回顾性研究;; 治疗结果;; 长春碱
6. The adenocarcinoma-specific stage shift in the Anti-lung Cancer Association project: Significance of repeated screening for lung cancer for more than 5 years with low-dose helical computed tomography in a high-risk cohort [J] . Nobuhiko Seki, Kenji Eguchi, Masahiro Kaneko Lung cancer: Journal of the International Association for the Study of Lung Cancer . 2010,第3期

机译：adenocarcinoma-specific阶段的转变Anti-lung癌症协会项目:重复筛查肺癌的重要意义与低剂量的癌症5年以上螺旋计算机断层扫描在高危人群
7. Stereotactic Ablative Radiotherapy versus Lobectomy for Operable Stage I Non-small-cell Lung Cancer: A Pooled Analysis of Two Randomized Trials——胸外科医生的解读 [O] . 许林 (Lin XU) 2015

机译：Stereotactic Ablative Radiotherapy versus Lobectomy for Operable Stage I Non-small-cell Lung Cancer: A Pooled Analysis of Two Randomized Trials——胸外科医生的解读
8. Fucoxanthin Attenuates Rifampin-Induced Cytochrome P450 3A4 (CYP3A4) and Multiple Drug Resistance 1 (MDR1) Gene Expression Through Pregnane X Receptor (PXR)-Mediated Pathways in Human Hepatoma HepG2 and Colon Adenocarcinoma LS174T Cells [O] . Liu, Cheng-Ling, Lim, Yun-Ping, Hu, Miao-Lin 2014

机译：Fucoxanthin attenuates Rifampin-Induced Cytochrome p450 3a4 (CYp3a4) and multiple Drug Resistance 1 (mDR1) Gene Expression Through pregnane X Receptor (pXR)-mediated pathways in Human Hepatoma HepG2 and Colon adenocarcinoma Ls174T Cells
9. Metodi Microbiologici Tradizionali e metodi molecolari per l'analisi degli integratori alimentari a base di o con probiotici per ujso umano (Microbiological and Molecular Methods for Analysis of Probiotic Based Food Supplements for Human Consumption). [R] . Aureli, P., Fiore, A., Scalfaro, C., 2008

机译：metodi microbiologici Tradizionali e metodi moleculeolari per l'analisi degli integratori alimentari a base di o con probiotici per ujso umano（microbiological and molecular methods for analysis of probiotic Based Food supplements for Human Consumption）。

Gene coexpression analysis offers important modules and pathway of human lung adenocarcinomas

摘要

著录项

相似文献

相关主题

期刊订阅